Objective To investigate the correlations of triglyceride glucose index（TyG） levels at different baselines with the risk of new-onset acute pancreatitis （AP） among the workers at Kailuan Group. Methods A total of 124 516 subjects were enrolled from 2006 to 2009 and followed up by health examinations of the workers in the group. The subjects with a history of AP or incomplete information on TG and FPG data were excluded. The cumulative incidence rate was determined by Log-Rank method. Multivariate Cox proportional hazards regression model was used to calculate hazard ratios （HR） for AP related to baseline TyG level after adjusting for the effects of multiple confunding factors. Results The subjects were divided into four groups （TyG ≤ 6.59， 6.59 < TyG ≤ 6.98， 6.98 < TyG4 ≤ 7.46， TyG > 7.46） according to the TyG levels， and the incidence of new-onset AP was observed in all the groups. For a follow-up of （12.59 ± 0.98 ）years， 399 cases of AP were observed. The corresponding incidence of AP in each tertile was 1.67， 2.32， 2.53， and 3.65 events per 10，000 person-years， respectively. After Cox analysis and correction of multiple confounding factors， the risk of AP incidence was increased in the TyG > 7.46 group， with an HR of 1.94［（95%CI（1.42， 2.65）， P < 0.01］. Conclusion TyG at its baseline of above 7.46 can increase the risk of AP.