The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 23: 3082 - 3086

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.23.010

Clinical Research

Characteristics of opportunistic infections in HIV⁃infected individuals with suboptimal immune reconstruction in Guangxi

  • Lei JI ,
  • Tiantian LI ,
  • Jianlin WU ,
  • Xianli XU ,
  • Chunlan ZHANG ,
  • Xiaojie LAO ,
  • Xinyin MEI ,
  • Yangni LU ,
  • Maowei. CHEN
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  • *.Wuming School of Clinical Medicine，Guangxi Medical University，Nanning 530199，China

Received date: 2023-06-20

  Online published: 2024-01-08

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Abstract

Objective To explore the characteristics of opportunistic infections （OIs） in HIV?infected individuals with suboptimal immune reconstitution after ART treatment so as to provide a reference for preventing and managing HIV infections. Methods The clinical data including opportunistic infections specifically were acquired from 112 HIV?infected individuals with suboptimal immune reconstitution from the outpatient department of Wuming Hospital， Guangxi Medical University. The impact of baseline CD4+T lymphocyte counts on the incidence， type， and mixed infection rates of the opportunistic infections were analyzed. Results The opportunistic infection rate among the 112 HIV?infected individuals with suboptimal immune reconstitution was 42.86%， among which fungal infections were the most commonly seen. The opportunistic infection rate of the patients with a baseline of CD4+T lymphocyte counts ≤ 50/μL was significantly higher than that of the patients with a baseline of CD4+T lymphocyte counts > 50/μL， and there was no significant difference in the type of opportunistic infections as well as the rate of mixed infections. Conclusion HIV?infected people with suboptimal immune reconstitution in Guangxi are susceptible to HIV OIs. Among them， the group with a baseline CD4+ T lymphocyte counts ≤ 50/μL has a higher rate of OIs， mainly fungal infections.

Key words： HIV; opportunistic infections; suboptimal immune reconstruction; antiretroviral therapy

Cite this article

Lei JI , Tiantian LI , Jianlin WU , Xianli XU , Chunlan ZHANG , Xiaojie LAO , Xinyin MEI , Yangni LU , Maowei. CHEN . Characteristics of opportunistic infections in HIV⁃infected individuals with suboptimal immune reconstruction in Guangxi[J]. The Journal of Practical Medicine, 2023 , 39(23) : 3082 -3086 . DOI: 10.3969/j.issn.1006-5725.2023.23.010

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