The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 22: 2994 - 3000

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.22.024

Modernization of Traditional Chinese Medicine

Cluster analysis of TCM syndrome types in patients with type 2 diabetic nephropathy and its relationship with disease staging

  • Yongming TIAN ,
  • Shifeng WU ,
  • Xi. ZHAO
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  • The First Affiliated Hospital of Tianjin University of Chinese Medicine，National Clinical Research Center for Chinese Medical Acupuncture & Moxibustion，Tianjin 300381，China

Received date: 2023-06-29

  Online published: 2023-12-11

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Abstract

Objective To explore the cluster analysis of TCM syndromes in patients with type 2 diabetic nephropathy （T2DN） and its relationship withdisease staging. Methods A total of 170 patients with T2DN admittedto our hospital from March 2020 to October 2022 were selected. The general dataof TCM syndromes of T2DN patients， and the distribution of TCM syndromes were observed， including the original TCM syndrome and the concurrent TCM syndrome. The cluster diagram was drawnby using systematic cluster analysis. The correspondence between TCM syndrome types and disease severity was analyzed by simple correspondence. Results The main TCM syndromes of early T2 DN， clinical T2 DN and end-stage renal disease （ESRD） were qi and yin deficiency with blood stasis syndrome （38.46%）， qi stagnation and phlegm stasis syndrome （37.88%）， qi stagnation and phlegm stasis syndrome （50.00%）. The different positions of the cluster diagram were intercepted， and the syndrome types were different. Among them， the D-point interception was divided into five syndromes： liver and kidney yin syndrome， heart and kidney deficiency syndrome， liver and stomach fire syndrome， qi and yin deficiency with stasis syndrome and qi stagnation and phlegm stasis syndrome. Among 170 patients with T2DN， there were 40 cases （23.53%） of liver and kidney yin syndrome， 26 cases （15.29%） of heart and kidney deficiency syndrome， 29 cases （17.06%） of liver and stomach fire syndrome， 20 cases （11.76%） of qi and yin deficiency with blood stasis syndrome， and 55 cases （32.35%） of qi stagnation and phlegm stasis syndrome. In the middle of the two-dimensional projection， qi and yin deficiency with blood stasis syndrome and qi stagnation and phlegm and blood stasis syndrome were not biased towards a certain grade of T2 DN lesion degree； the liver-stomach fire syndrome was biased towards stage V， the heart-kidney deficiency syndrome was biased towards stage Ⅳ， and the liver-kidney yin syndrome was biased towards stage Ⅰ-Ⅲ. Conclusion The basic TCM syndromes of T2 DN patients were liver and kidney yin， heart and kidney deficiency， liver and stomach fire， qi and yin deficiency with blood stasis and qi stagnation and phlegm and blood stasis. With the development of T2DN， TCM syndromes gradually changed from liver and kidney yin to heart and kidney deficiency to liver and stomach fire， and qi and yin deficiency with blood stasis and qi stagnation and phlegm stasis accompanied T2DN patients at all stages.

Key words： type 2 diabetic nephropathy; TCM syndrome type; cluster analysis; staging

Cite this article

Yongming TIAN , Shifeng WU , Xi. ZHAO . Cluster analysis of TCM syndrome types in patients with type 2 diabetic nephropathy and its relationship with disease staging[J]. The Journal of Practical Medicine, 2023 , 39(22) : 2994 -3000 . DOI: 10.3969/j.issn.1006-5725.2023.22.024

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