The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 22: 2953 - 2957

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.22.016

Clinical Research

Correlation between sdLDL⁃C， CXCL12 and CVD in diabetic patients

  • Li′na MA ,
  • Zhenhua CAO ,
  • Bing. YANG
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  • *.Tianjin Hospital，Tianjin 300211，China

Received date: 2023-06-28

  Online published: 2023-12-11

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Abstract

Objective To investigate the correlation between serum levels of small dense low density lipoprotein-cholesterol （sdLDL-C） and chemokine CXC motifligand12 （CXCL12） and diabetes mellitus with cardiovascular disease（CVD）. Methods A total of 256 diabetic patients treated in our hospital between June 2021 and September 2022 were selected as the diabetic group. The patients were grouped according to whether they had combined CVD or not. And the serum sdLDL-C as well as CXCL12 levels of each group were compared with healthy volunteers. Risk factors for the complication of CVD in diabetic patients were analyzed. To analyze the diagnostic value of sdLDL-C， CXCL12 and combined test for diabetic patients with complicated CVD. Results Serum sdLDL-C and CXCL12 levels were higher in the diabetes group than in the control group （P < 0.05）. The duration of disease， BMI， LDL-C， and serum sdLDL-C and CXCL12 levels were higher in the cardiovascular disease group than in the non-cardiovascular disease group （P < 0.05）. A multifactorial logistic regression analysis showed that sdLDL-C and CXCL12 were independent risk factors for the complication of CVD in diabetic patients （P < 0.05）. The sensitivity and specificity of serum sdLDL-C and CXCL12 combined test were higher than that of single test. Conclusion Elevated serum sdLDL-C and CXCL12 levels in patients with diabetes mellitus are independent risk factors for the complication of CVD， and the combination of these two tests has a high diagnostic value for diabetes mellitus with CVD.

Key words： diabetes; small dense low-density lipoprotein cholesterol; chemokine CXC motif ligand12; atherosclerotic cardiovascular disease

Cite this article

Li′na MA , Zhenhua CAO , Bing. YANG . Correlation between sdLDL⁃C， CXCL12 and CVD in diabetic patients[J]. The Journal of Practical Medicine, 2023 , 39(22) : 2953 -2957 . DOI: 10.3969/j.issn.1006-5725.2023.22.016

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