The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 20: 2618 - 2622

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.20.011

Clinical Research

Expression and clinical significance of MUC5AC in airway of children with mycoplasma pneumoniae pneumonia

  • Li PENG ,
  • Lili ZHONG ,
  • Lin LIN ,
  • Han HUANG ,
  • Xiaofang DING ,
  • Min CHEN ,
  • Xiaojuan. LIN
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  • the First Affiliated Hospital of Hu′nan Normal University，Pediatric Medical Center，Hu'nan Provincial People's Hospital，Hu'nan Provincial Key Laboratory of Pediatric Respirology，Changsha 410005，China

Received date: 2023-05-05

  Online published: 2023-11-15

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Abstract

Objective To investigate the expression of mucin 5AC （MUC5AC） in airway of children with mycoplasma pneumoniae pneumonia（MPP）， and to provide clinical value for early diagnosis and treatment of MPP mucus plug. Methods A total of 94 children with MPP who were hospitalized for alveolar lavage from April 2022 to October 2022 were included in the MPP group. According to whether mucus plug was observed under the first fiberoptic bronchoscope， the MPP group was divided into mucus plug group （n = 41） and non-mucus plug group （n = 53）. Relevant clinical data and laboratory examination data were collected. Results Compared with non mucus plug group， the mucus plug group had a longer heat duration and hospital stay， and the levels of CRP， LDH，PCT， D-dimer， MP-DNA copy value of lavage fluid， IL-17， MUC5AC were all increased，with statistically significant differences （P < 0.05）. MUC5AC was positively correlated with LDH and IL-17 levels （r = 0.54， P = 0.002； r = 0.39， P = 0.019）. The ROC curve plotted based on the level of MUC5AC had an area under the ROC curve of 0.811， a sensitivity of 86.2% and a specificity of 71.4% for predicting formation of mucus plug in MPP. Conclusions There was an increase in the level of MUC5AC in children with mucus plug group in MPP， and the level of MUC5AC had a certain value for predicting mucus plug formation.

Key words： child; mycoplasma pneumoniae pneumonia; MUC5AC

Cite this article

Li PENG , Lili ZHONG , Lin LIN , Han HUANG , Xiaofang DING , Min CHEN , Xiaojuan. LIN . Expression and clinical significance of MUC5AC in airway of children with mycoplasma pneumoniae pneumonia[J]. The Journal of Practical Medicine, 2023 , 39(20) : 2618 -2622 . DOI: 10.3969/j.issn.1006-5725.2023.20.011

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