The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 18: 2405 - 2410

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.18.021

Reviews

The neuroregulatory effects and potential applications of urolithins in mental disorders

  • Zhengyuan HUANG ,
  • Lirong ZHAO ,
  • Kexuan ZHANG ,
  • Gaohua WANG ,
  • Benhong. ZHOU
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  • 1.Mental Health Center，Renmin Hospital，Wuhan University，Wuhan 430060，China

Received date: 2023-05-17

  Online published: 2023-10-10

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Abstract

Mental disorders are a group of complex neurological conditions with unclear etiologies， characterized by abnormalities in cognitive， emotional， volitional， and behavioral functions. The prevalence of mental disorders is increasing， whereas the development of effective drugs has been slow， greatly impacting the mental and physical well-being and quality of life in patients. Consequently， the development and application of new drugs have become a hot topic in current research. In recent years， urolithins， as natural bioactive compounds， have garnered widespread attention among researchers. By crossing the blood-brain barrier， urolithins play neuroprotective roles including anti-inflammatory， antioxidant， and anti-apoptotic effects. They are considered potential small molecules for modulating the nervous system， with potential clinical applications for symptom improvement and rehabilitation in mental disorders. However， no research on the application of urolithins for mental disorders has been currently reported. In this review， we summarize the recent domestic and international research on the neuroregulatory mechanisms and therapeutic potential of urolithins for mental disorders， aiming to provide new directions for research in mental disorders and offer novel insights for the development and clinical conversion of urolithin-based treatments for mental disorders.

Key words： urolitrin; schizophrenia; depressive disorder; neuroregulation

Cite this article

Zhengyuan HUANG , Lirong ZHAO , Kexuan ZHANG , Gaohua WANG , Benhong. ZHOU . The neuroregulatory effects and potential applications of urolithins in mental disorders[J]. The Journal of Practical Medicine, 2023 , 39(18) : 2405 -2410 . DOI: 10.3969/j.issn.1006-5725.2023.18.021

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