The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 18: 2373 - 2378

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.18.015

Clinical Research

Effect of fasting plasma glucose level on the prognosis of disease in patients with HBV⁃related acute⁃on⁃chronic liver failure

  • Haibin WANG ,
  • Hui LI ,
  • Xiaolei CHEN ,
  • Na LIU ,
  • Quanmei LI ,
  • Yu ZOU ,
  • Chunmei LI ,
  • Jingquan GAN ,
  • Changhui WU ,
  • Huaxian CHEN ,
  • Xiang LIU ,
  • Ming. GONG
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  • 1.Department of Infectious Diseases
    2.the Affiliated Hospital of YunNan University（the Second People's Hospital of YunNan Province），Kunming 650000，China

Received date: 2023-06-18

  Online published: 2023-10-10

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Abstract

Objective To explore the effect of fasting blood glucose（FPG） on the prognosis of disease in patients with HBV-related acute-on-chronic liver failure. Methods The clinical data of 109 HBV-related ACLF patients admitted to the Department of Infectious Diseases of a tertiary a hospital in Yunnan Province were retrospectively analyzed， and grouped according to different FPG levels and prothrombin international standardized ratio（PT-INR） of prothrombin. ANOVA test， Chi-square test， Spearman correlation analysis and binary logistic regression were used to analyze the effect of FPG level on the prognosis of disease of HBV-related ACLF patients. Results The incidence and mortality of HBV-related ACLF complications （HE， hyponatremia， SBP） in low FPG group were higher than those in normal FPG and high FPG group （P < 0.05）. The incidence of low FPG and mortality of patients in middle-late stage group were higher than those in pre-early stage group （P < 0.05）. Child-Pugh score， MELD score and INR were positively correlated （P < 0.001）. Binary Logistic regression analysis showed that low FPG and normal FPG were independent risk factors for disease progression in HBV-related ACLF patients （OR = 0.174， 95%CI： 0.066 ~ 0.461，P < 0.05）. Conclusion Low FPG increases the risk of worsening disease progression in patients with HBV-related ACLF， while high FPG may play a role in protecting liver function.

Key words： hepatitis B virus; acute-on-chronic liver failure; fasting plasma glucose; risk factors; protection

Cite this article

Haibin WANG , Hui LI , Xiaolei CHEN , Na LIU , Quanmei LI , Yu ZOU , Chunmei LI , Jingquan GAN , Changhui WU , Huaxian CHEN , Xiang LIU , Ming. GONG . Effect of fasting plasma glucose level on the prognosis of disease in patients with HBV⁃related acute⁃on⁃chronic liver failure[J]. The Journal of Practical Medicine, 2023 , 39(18) : 2373 -2378 . DOI: 10.3969/j.issn.1006-5725.2023.18.015

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