The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 18: 2289 - 2293

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.18.001

Feature Reports：lumbar spine disease

Analysis of the relationship between FGF⁃1 and VEGF expression in the ligamentum flavum of patients with lumbar spinal stenosis and restenosis after decompression

  • Yaoxin CHEN ,
  • Songbo LI ,
  • Guanjun FANG ,
  • Guobiao YE ,
  • Xianyin. LIU
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  • Department of Orthopedics，Dongguan Hospital Affiliated to Southern Medical University，Dongguan 523000，China

Received date: 2023-06-12

  Online published: 2023-10-10

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Abstract

Objective To investigate the relationship between the expressions of fibroblast growth factor 1 （FGF?1） and vascular endothelial growth factor （VEGF） in the ligamentum luteum in patients with lumbar spinal stenosis （LSS） and restenosis after decompression. Methods 138 LSS patients underwent lumbar decompression were selected， including mild group ［absolute claudication distance （ACD） ≤ 200 m， 41 cases］， moderate group （ACD 201 ~ 400 m， 67 cases） and severe group （ACD > 400 m， 30 cases）， and 138 non?LSS patients were selected as control group. The expressions of FGF?1 and VEGF in ligamentum flavum were detected， and the restenosis was measured after the operation. Results The expression of FGF?1 in LSS group was lower than that in control group （P < 0.001）， and the expression of VEGF was higher than that in control group （P < 0.001）. The expression of FGF?1 in severe group was lower than that in moderate and low degree groups （P < 0.05）， and the expression of VEGF was higher than that in moderate and low degree groups （P < 0.05）. Severe spinal stenosis， incomplete decompression and high expression of VEGF were risk factors for restenosis after lumbar decompression in patients with LSS （P < 0.05，P < 0.001）， and FGF?1 was protective factor （P < 0.05）. Conclusion FGF?1 expression decreased and VEGF expression increased in ligamentum flavum of LSS patients， which was related to the degree of spinal canal stenosis and postoperative restenosis.

Key words： lumbar spinal stenosis; lumbar decompression; fibroblast growth factor 1; vascular endothelial growth factor

Cite this article

Yaoxin CHEN , Songbo LI , Guanjun FANG , Guobiao YE , Xianyin. LIU . Analysis of the relationship between FGF⁃1 and VEGF expression in the ligamentum flavum of patients with lumbar spinal stenosis and restenosis after decompression[J]. The Journal of Practical Medicine, 2023 , 39(18) : 2289 -2293 . DOI: 10.3969/j.issn.1006-5725.2023.18.001

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