The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 16: 2106 - 2111

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.16.016

Clinical Research

Correlations between clinical characteristics and cytokines in primary Sjogren syndrome

  • Min SU ,
  • Shan SU ,
  • Shulin SONG ,
  • Chongling SUN ,
  • Huifang ZHANG ,
  • Xiaofeng GUO ,
  • Kai WANG ,
  • Ming LI ,
  • Xingzi. LI
Expand
  • *.Department of Rheumatology and Immunology，The First College of Clinical Medical Science，China Three Gorges University，Yichang Central People′s Hospital，Yichang 443000，China

Received date: 2023-05-24

  Online published: 2023-09-26

Fold

Abstract

Objective To investigate the clinical characteristics and disease activity as well as their correlations with cytokine of patients with primary Sjogren syndrome （pSS）. Methods The clinical data of pSS patients hospitalized in our department were retrospectively analyzed. The patients were divided into different groups according to age， gender， pathology of labial gland and disease activity. The differences in clinical characteristics， cytokine and the relations between them were analyzed retrospectively. Results Totally， 91 cases were included in the study. Among them， the ratio between male and female was about 1∶17.2 and 74.73% of the patients were elderly （≥ 50 years） and 25.27% were young and middle-aged （< 50 years）. The labial gland biopsy revealed Chsholm grade I or above in 57.14% of patients. 93.41% of the patients developed extraglandular involvement. Lymphadenopathy was the most common （50.55%） in extraglandular manifestations， followed by pancytopenia （45.05%） and elevated immunoglobulin （40.66%）. The main manifestations of the male pSS patients were arthritis/arthralgia， interstitial pneumonia disease， pancytopenia and elevated immunoglobulin. The young and middle-aged group had higher rates of fever and hypocomplementemia than the elderly group， while the latter had a higher rate of pancytopenia （especially granulocytopenia） than the young and middle-aged group （P < 0.01）. The group with focal lymphocytic sialadenitis had higher rater of globulin elevation than the group without focal lymphocytic sialadenitis. EULAR Sjogren′s syndrome disease activity index （ESSDAI） and FS were negatively correlated with age. The increase rates of serum IL-2R， IL-8， TNFa in the group of moderate and high disease activity were significantly higher than those in the group with low disease activity. Conclusion The elderly pSS patients are more susceptible for pancytopenia， but their disease activity and extraglandular manifestations are less patent and serious， as compared to young and middle-aged patients. The patients with focal lymphocytic sialadenitis are more likely to be affected with salivary gland enlargement and elevated globulin. The increases of serum IL-2R， IL-8 and TNFa are more commonly seen in those patients with moderate and high disease activity.

Key words： primary Sjogren syndrome; EULAR Sjogren syndrome disease activity index; focus index; interleukin-2 receptor; interleukin-8; tumor necrosis factor α

Cite this article

Min SU , Shan SU , Shulin SONG , Chongling SUN , Huifang ZHANG , Xiaofeng GUO , Kai WANG , Ming LI , Xingzi. LI . Correlations between clinical characteristics and cytokines in primary Sjogren syndrome[J]. The Journal of Practical Medicine, 2023 , 39(16) : 2106 -2111 . DOI: 10.3969/j.issn.1006-5725.2023.16.016

References

1 VITALI C， BOMBARDIERI S， JONSSON R， et al. Classification criteria for sjogren's syndrome： a revised version of the European criteria proposed by the American European Consensus Group［J］. Ann Rheum Dis， 2002， 61 （6）：554-558．
2 CHISHOLM D M， MASON D K. Labial salivary gland biopsy in Sj?gren's disease［J］. J Clin Pathol，1968，21 （5）： 656-660.
3 RADENSKA-LOPOVOK S G， KARANOVA M S， ZANOZIN A S， et al. Evaluation of morphological activity of primary Sjogren's syndrome on bioptates of minor salivary glands［J］. Arkh Patol， 2023，85（1）：5-9.
4 LONGOBARDI S， LOPEZ-DAVIS C， KHATRI B，et al. Autoantibodies identify primary Sj?gren's syndrome in patients lacking serum IgG specific for Ro/SS-A and La/SS-B［J］. Ann Rheum Dis， 2023，82（9）：1181-1190.
5 中国医师协会风湿免疫科医师分会干燥综合征学组.原发性干燥综合征诊疗规范［J］. 中华内科杂志，2020，59（4）： 269-276.
6 FLORES-CHáVEZ A， KOSTOV B， SOLANS R， et al. Severe，life-threatening phenotype of primary Sj?gren's syndrome： clinical characterisation and outcomes in 1580 patients （GEAS-SS Registry）［J］. Clin Exp Rheumatol， 2018， 112（3）：121-129.
7 李慧敏，余陈欢，黄燕静，等. 400例干燥综合征患者临床并发症的特点分析［J］. 国际流行病学传染病学杂志，2019，46（3）：247-250.
8 LIAMPAS A， PARPERIS K， EROTOCRITOU M F， al et， Primary Sj?gren syndrome-related peripheral neuropathy： A systematic review and meta-analysis［J］. Eur J Neurol， 2023，30（1）：255-265.
9 AFZALI A M， MOOG P， KALLURI S R， et al. CNS demyelinating events in primary Sj?gren's syndrome： A single-center case series on the clinical phenotype［J］. Front Neurol， 2023，14：1128315.
10 BERARDICUTI O， MARINO A， GENOVALI I， et al. Interstitial Lung Disease and Pulmonary Damage in Primary Sj?gren's Syndrome： A Systematic Review and Meta-Analysis［J］. J Clin Med，2023，12（7）：2586.
11 VIRDEE S， GREENAN-BARRETT J， CIURTIN C. A systematic review of primary Sj?gren's syndrome in male and paediatric populations［J］. Clin Rheumatol， 2017，36（10）：2225-2236.
12 宣磊，王景，董振华. 65例男性干燥综合征患者的临床特点分析［J］. 医学研究杂志，2017，46（12）：137-140.
13 罗静，陈嘉琪，张丽宁，等. 不同性别和年龄起病原发性干燥综合征患者临床特点比较［J］. 中华风湿病学杂志，2021，25（12）：793-799.
14 陈志锋，田静，欧阳若芸. 原发性干燥综合征合并肺动脉高压的临床特征和危险因素［J］. 中南大学学报（医学版）， 2023， 48（3）： 339-346.
15 GOULES A V， ARGYROPOULOU O D， PEZOULAS V C， et al. Primary Sj?gren's Syndrome of Early and Late Onset： Distinct Clinical Phenotypes and Lymphoma Development［J］. Front Immunol， 2020，11： 594096.
16 ZHANG Y， QIAO L， ZHANG L， Renal tubular acidosis and associated factors in patients with primary Sj?gren's syndrome： a registry-based study［J］. Clin Rheumatol， 2023，42（2）：431-441.
17 CHATTERJEE R， BALAKRISHNAN A， KHARBANDA R， et al.Renal involvement in Sj?gren's syndrome： predictors and impact on patient outcomes［J］. Rheumatol Int， 2023，43（7）：1297-1306.
18 GONG Y， LIU H， LI G， et al.Childhood-onset primary Sj?gren's syndrome in a tertiary center in China： clinical features and outcome［J］. Pediatr Rheumatol Online J， 2023，21（1）：11.
19 LIN J C， PAN K L， LI C F， et al. Altered subgroups of regulatory T cells in patients with primary Sj?gren's syndrome［J］. Heliyon， 2023，9（5）：e15565.
20 CHETT G， DAYER J M， MANGER B， et al. Interleukin-1 function and role in rheumatic disease［J］. Nat Rev Rheumatol， 2016， 12 （1） ：14-24.
21 ?ZCAKA ?， ALP?Z E， NALBANTSOY A， al et， Clinical periodontal status and inflammatory cytokines in primary Sj?gren's syndrome and rheumatoid arthritis ［J］. J Periodontol， 2018，89（8）：959-965.
22 ZHANG S， QU J， WANG L， al et， Activation of Toll-Like Receptor 7 Signaling Pathway in Primary Sj?gren's Syndrome-Associated Thrombocytopenia［J］. Front Immunol， 2021，12：637659.
23 AKIYAMA M， SASAKI T， KANEKO Y， al et， Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG 4 -related disease and primary Sj?gren's syndrome adults from a defined population［J］. Clin Exp Rheumatol， 2018， 112（3）：157-164.
24 房星星，路臻豪，汤建平，等. MSCs通过促分泌TGF-β1、IL-6和IL-10抑制干燥综合征患者CD4+ T细胞的活化增殖［J］. 同济大学学报（医学版），2016，37（4）：31-35.
25 CHEN C， LIANG Y， ZHANG Z， al et， Relationships between increased circulating YKL-40， IL-6 and TNF-α levels and phenotypes and disease activity of primary Sj?gren's syndrome［J］. Int Immunopharmacol， 2020，88：106878.
Options
Outlines

/

〈 〉