The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 16: 2071 - 2076

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.16.010

Clinical Research

Correlation of serum autophagy⁃related protein 9a and galectin⁃3 with left ventricular hypertrophy in essential hypertension patients

  • Yang LI ,
  • Sijin YANG ,
  • Houping XU ,
  • Gang LUO ,
  • Xianlun PANG ,
  • Suqiong HUANG ,
  • Zhongfang. ZHOU
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  • The Affiliated Traditional Chinese Medicine Hospital，Southwest Medical University，Luzhou 646000，China

Received date: 2023-05-12

  Online published: 2023-09-26

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Abstract

Objective To investigate the correlation of serum autophagy-related protein 9a（ATG9a） and galectin-3 （Gal-3）with left ventricular hypertrophy （LVH） in essential hypertension （EH） patients. Methods A total of 84 patients with EH （NLVH group） and 69 patients with EH combined with LVH （LVH group） who underwent physical examination at the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical Universityfrom July 2020 to December 2022 were recruited prospectively，and another 115 healthy individuals who taking physical examination during the same period were included as the control group. The correlation of serum ATG9a and Gal-3 levels with LVH was analyzed in the patients with EH. Results Compared with the control group， the NLVH group and LVH group had significantly higher proportion of combined coronary heart disease and proportion of combined dyslipidemia， abnormal body mass index， increased systolic and diastolic blood pressure and homocysteine， alanine aminotransferase， triglycerides， total cholesterol， fasting blood glucose， LVPWTD， IVSTD， LVMI， and elevated ATG9a and Cal-3 level， but lower HDL-C level（P < 0.05）. Obviously longer course of hypertension， increased systolic and diastolic blood pressure， LVPWTD， LVEDD， IVSTD， LVMI， ATG9a， and Cal-3 in the LVH group were observed when compared with those in the NLVH group（P < 0.05）. ROC curve analysis showed that the areas under the curve for serum ATG9a and Cal-3 level was 0.829 （95% CI： 0.765 ~ 0.893） and 0.819 （95% CI： 0.753 ~ 0.884）， respectively， with significant differences （P < 0.001）. Conclusion Serum ATG9a and Cal-3 are correlated with LVH in patients with EH， and they can be regarded as clinical indicators in the auxiliary diagnosis and prognostic assessment for patients with EH with LVH.

Key words： essential hypertension; left ventricular hypertrophy; autophagy-related protein 9a; galectin-3

Cite this article

Yang LI , Sijin YANG , Houping XU , Gang LUO , Xianlun PANG , Suqiong HUANG , Zhongfang. ZHOU . Correlation of serum autophagy⁃related protein 9a and galectin⁃3 with left ventricular hypertrophy in essential hypertension patients[J]. The Journal of Practical Medicine, 2023 , 39(16) : 2071 -2076 . DOI: 10.3969/j.issn.1006-5725.2023.16.010

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