The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 16: 2017 - 2021

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.16.002

Clinical Advances

Research progress on the involvement of podoplanin in inflammatory response

  • Shiyao LIU ,
  • Yiming. ZHAO
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  • Jiangsu Institute of Hematology，Hemostasis and Thrombosis Laboratory，First Affiliated Hospital of Soochow University，Suzhou 215000，China

Received date: 2023-02-03

  Online published: 2023-09-26

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Abstract

Podoplanin （PDPN） is a relatively conserved sialic acid transmembrane mucin， which is often expressed in different types of cell tissues such as fibroblasts， alveolar cells and glomerular podocytes in ontogenetic development， and participates in the embryonic development， immune response， and malignant progression of cancer. Acute inflammation is a series of red，swollen，hot，painful defense reactions when the body is stimulated，which has a certain protective effect on the body，but when acute inflammation gradually develops into chronic inflammation， it will have a certain harmful effect on the body and lead to disease. In recent years， studies have shown that when the body produces inflammation，the expression of PDPN in various cell tissues is upregulated，such as fibroblasts， T cells and macrophages， etc.， and is also expressed in inflammatory diseases， such as multiple sclerosis， rheumatoid arthritis and systemic sclerosis，and PDPN mainly interacts with adjacent cells or proteins to regulate cell proliferation，contraction，migration，colonization and other behaviors to participate in the occurrence and development of inflammatory diseases. This article will mainly review the structure， function， function and mechanism of PDPN in inflammation.

Key words： podoplanin; inflammation; mechanism; function

Cite this article

Shiyao LIU , Yiming. ZHAO . Research progress on the involvement of podoplanin in inflammatory response[J]. The Journal of Practical Medicine, 2023 , 39(16) : 2017 -2021 . DOI: 10.3969/j.issn.1006-5725.2023.16.002

References

1 SINGH N， BABY D， RAJGURU J P，et al. Inflammation and cancer［J］. Ann Afr Med， 2019， 18（3）： 121-126.
2 PAYNE H， PONOMARYOV T， WATSON S P，et al. Mice with a deficiency in CLEC-2 are protected against deep vein thrombosis［J］. Blood， 2017， 129（14）： 2013-2020.
3 QUINTANILLA M， MONTERO-MONTERO L， RENART J，et al. Podoplanin in Inflammation and Cancer［J］. Int J Mol Sci， 2019， 20（3）： 707.
4 NAVARRO A， PEREZ R E， REZAIEKHALIGH M H，et al. Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42［J］. Am J Physiol Lung Cell Mol Physiol， 2011， 300（1）： L32-L42.
5 KARIN M， CLEVERS H. Reparative inflammation takes charge of tissue regeneration［J］. Nature， 2016， 529（7586）： 307-315.
6 BALDWIN M J， MIMPEN J Y， CRIBBS A P，et al. Electrospun Scaffold Micro-Architecture Induces an Activated Transcriptional Phenotype within Tendon Fibroblasts［J］. Front Bioeng Biotechnol， 2022， 9： 795748.
7 ZHANG Z， ZHANG N， YU J，et al. The Role of Podoplanin in the Immune System and Inflammation［J］. J Inflamm Res， 2022， 15： 3561-3572.
8 YASUDA K， TAKEUCHI Y， HIROTA K. The pathogenicity of Th17 cells in autoimmune diseases［J］. Semin Immunopathol， 2019， 41（3）： 283-297.
9 CHEOK Y Y， TAN G M Y， FERNANDEZ K C，et al. Podoplanin Drives Motility of Active Macrophage via Regulating Filamin C During Helicobacter pylori Infection［J］. Front Immunol， 2021， 12： 702156.
10 FEI M， WANG H， ZHOU M，et al. Podoplanin influences the inflammatory phenotypes and mobility of microglia in traumatic brain injury［J/OL］. Biochem Biophys Res Commun， 2020， 523（2）： 361-367.
11 XIE Z， SHAO B， HOOVER C，et al. Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function［J］. JCI Insight， 2020， 5（13）： e134749.
12 RAYES J， LAX S， WICHAIYO S，et al. The podoplanin-CLEC-2 axis inhibits inflammation in sepsis［J］. Nat Commun， 2017， 8（1）： 2239.
13 LAX S， RAYES J， WICHAIYO S，et al. Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse［J］. Am J Physiol Lung Cell Mol Physiol， 2017， 313（6）： L1016-L1029.
14 SUZUKI-INOUE K. Platelets and cancer-associated thrombosis： focusing on the platelet activation receptor CLEC-2 and podoplanin［J］. Blood， 2019， 134（22）： 1912-1918.
15 LENTI M V， ROSSI C M， MELAZZINI F，et al. Seronegative autoimmune diseases： A challenging diagnosis［J］. Autoimmun Rev， 2022， 21（9）： 103143.
16 孟凡， 陈峻， 刘雨霞，等， Dock 2通过调节T细胞活性和抗原特异性IgG抗体的产生来控制肠道柠檬酸杆菌感染 ［J］. 实用医学杂志， 2021， 37（8）： 1000-1007.
17 ORANGE D E， YAO V， SAWICKA K，et al. RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares［J/OL］. N Engl J Med， 2020， 383（3）： 218-228.
18 ASAI J. The Role of Podoplanin in Skin Diseases［J］. Int J Mol Sci， 2022， 23（3）： 1310.
19 CIMINI M， KISHORE R. Role of Podoplanin-Positive Cells in Cardiac Fibrosis and Angiogenesis After Ischemia［J］. Front Physiol， 2021， 12： 667278.
20 CARPINTERO-FERNANDEZ P， VARELA-EIRIN M， LACETERA A，et al. New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors［J］. Biomolecules， 2020， 10（4）： 637.
21 HUANG Y， LU M， WANG Y，et al. Podoplanin： A potential therapeutic target for thrombotic diseases［J］. Front Neurol， 2023， 14： 1118843.
22 MENG D， LUO M， LIU B. The Role of CLEC-2 and Its Ligands in Thromboinflammation［J］. Front Immunol， 2021， 12： 688643.
23 MENG D， MA X， LI H，et al. A Role of the Podoplanin-CLEC-2 Axis in Promoting Inflammatory Response After Ischemic Stroke in Mice［J］. Neurotox Res，2021， 39（2）： 477-488.
24 NAKATA Y， KONO H， AKAZAWA Y，et al. Role of podoplanin and Kupffer cells in liver injury after ischemia-reperfusion in mice［J］. Surg Today， 2022， 52（2）： 344-353.
25 QIAN S， QIAN L， YANG Y，et al. Podoplanin neutralization reduces thrombo-inflammation in experimental ischemic stroke by inhibiting interferon/caspase-1/GSDMD in microglia［J］. Ann Transl Med， 2022， 10（18）： 979-979.
26 QIAN S， QIAN L， YANG Y，et al. Transcriptome sequencing analysis revealed the molecular mechanism of podoplanin neutralization inhibiting ischemia/reperfusion-induced microglial activation［J］. Ann Transl Med， 2022， 10（11）： 638.
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