Objective To investigate the factors influencing the hesitation of occupational pneumoconiosis patients in Guangdong Province to receive COVID ­ 19 vaccine so as to provide reference for eliminating their “vaccine hesitancy”. Methods From September 2022 to November 2022， a cohort of patients aged 18 years and above were selected from Guangdong occupational pneumoconiosis report system as the subjects in the survey by systematic sampling method. Questionnaire survey was conducted by telephone follow ­ up，and the acquired data were analyzed by multiple stepwise regression. Results A total of 339 questionnaires meeting the requirements were obtained， including 14 items affecting factors of “vaccine hesitation”. According to the standard partial regression coefficient，nine factors were correlated with vaccine hesitancy，in the order from the largest to the smallest correlation，e.g.，“I would be more willing to get vaccinated if recommended by doctors，community and other professionals，”“I believe that vaccines approved by the state are safe，” and “If the government recommends vaccination，I believe it will be beneficial.”，etc. Conclusion The government should carry out psychological interventions for coping strategies and health education measures to provide objective information about existing and developing vaccines and meanwhile pay more attention to the vaccine hesitancy of occupational disease patients so so to increase the vaccination rate and eliminate their vaccine hesitancy for the ultimate purpose of giving full play to the important protective role of the novel coronavirus vaccine in preventing Covid­19.