Objective To investigate the clinical efficacy of single row anchor combined with bone tunnel （SRA-BT） and proximal humeral plate （PHP） in treatment of greater tuberosity （GT） fractures of humerus. Methods The medical records of 44 patients with GT fracture admitted from June 2017 to June 2021 were retrospectively analyzed. They were divided into SRA-BT group （18 cases）and PHP group （26 cases）by different surgical methods. Perioperative related indicators，complications，bone healing， and postoperative re-displacement distance of GT were compared between the two groups. VAS，ASES and protractor measurements were used to evaluate the pain degree ， function status and range of motion （ROM） at 6 months follow-up ， respectively. Results The length of incision，operation time，intraoperative blood loss and in-patients costs in PHP group was significantly higher than that in SRA-BT group （P < 0.05）. The re-displacement distance of GT in SRA-BT group was greater than that of PHP group （P < 0.05）. There was no significant difference in postoperative complications between the two groups （P > 0.05）. The postoperative VAS scores at rest and activity in the two groups were significantly better than those in preoperative （P < 0.05）， but there was no significant difference between the two groups （P > 0.05）. The postoperative ASES scores of the two groups were significantly better than that in preoperative （P < 0.05）， and the postoperative ASES scores of SRA-BT group were higher than those in PHP group（P < 0.05）.The ROM of the RA-BT group was better than that of the PHP group during flexion and abduction （P < 0.05）， but there was no significant difference between the two groups at 0 ° external rotation and 90 ° internal rotation （P > 0.05）. Conclusion Both SRA-BT and PHP can achieve good clinical efficacy and prognosis in the treatment of GT fractures. However， SRA-BT has the advantages of less trauma， low cost， relatively few postoperative complications， and no need for a second operation.