Objective To investigate the effects of Bacillus subtilis and enterococcus faecium enteric⁃coated capsules on intestinal barrier function and Th9 cell expression in cirrhotic patients with different liver reserve func⁃ tion. Methods A total of 172 patients with liver cirrhosis in our hospital were selected and assigned to observation group（72 children Pugh A grad）and control group（100 children Pugh B⁃C grade）based on different liver reserve functions. All patients were treated with conventional treatment in addition to the use of metoprolol（Bacillus subtil⁃ is enteric coated capsules），and both were observed for 14 days. Results After treatment，the total effective rates in the observation group and the control group were 98.6% and 89%，and the observation group was better than that of the control group（P < 0.05）. there was no significant difference in intestinal flora between the two groups before treatment（P > 0.05），the Bifidobacterium and Lactobacillus in the observation group after treatment were significantly increased（P < 0.05），Candida albicans was significantly lower than that before treatment（P < 0.05）. after treatment，the serum IL⁃6 and TNF⁃α in the observation group and the control group were lower than before treatment（P < 0.05），and the serum IL ⁃6 and TNF ⁃α in the observation group after treatment were lower than those in the control group（P < 0.05）. after treatment，the Th9 cells in the observation group and the control group were（0.11 ± 0.05）% and（0.32 ± 0.10）%（P < 0.05），respectively，which were lower than（0.82 ± 0.32）% and （0.83 ± 0.24）% before treatment，and the Th9 cells in the observation group after treatment was lower than those in the control group（P < 0.05）. Conclusion Compared with patients with poor hepatic reserve function，application of Bacillus subtilis and enterococcus faecium enteric⁃coated capsule in the better hepatic reserve function patients with liver cirrhosis could improve the intestinal barrier function，inhibit the expression of Th9 cells，inhibit the expression of inflammatory cytokines，which play a better therapeutic effect.