Pancreatic cancer（PC），as one of the digestive tract tumors with the lowest survival rate and the worst prognosis，is known as the“king of cancers”. Most patients have lost the opportunity for radical resection at diagnosis and have developed resistance to gemcitabine（GEM），the first ⁃line chemotherapy agent，further reducing the effectiveness of treatment. In recent years，ferroptosis a new type of iron⁃dependent cell programmed death，and its regulatory mechanism has been widely studied and applied in the treatment of pancreatic cancer. Ex⁃ perimental studies have shown that inducing ferroptosis in pancreatic cancer cells can effectively reduce their resis⁃ tance to chemotherapy drugs. In this paper，the role of ferroptosis in gemcitabine resistance of pancreatic cancer were reviewed，aiming to provide new ideas and directions for the study of the treatment of pancreatic cancer based on ferroptosis.