Modern medical clinical decision ⁃ making are increasingly dependent on medical laboratory， which holds true for tuberculosis. However，so far the data of clinical practice have demonstrated that pathogenic evidences have not been obtained for more than 40% of tuberculosis cases from clinical laboratory. And delays occurring in the process of diagnosis and treatment are also general.Accurate and rapid laboratory techniques and methods have always been eagerly anticipated. This review tries to discuss the needs and problems to medical lab⁃ oratory for clinical diagnosis，precision medicine，prevention and control of tuberculosis.Our some simple cognition on how to get human out of the trouble are briefly given.