Objective To investigate the effect of warm acupuncture and moxibustion combined with Jianpi Tongluo Formula on inflammatory factors and bone metabolism in patients with rheumatoid arthritis（RA）. Methods A total of 108 patients with RA in hospital from June 2020 to June 2022 were selected and divided into western medicine group（39 cases）and combination group（69 cases）by random number table method. The western medi⁃ cine group received conventional treatment with western medicines；The combined group was treated with warm acupuncture and moxibustion combined with Jianpi Tongluo Formula. TCM syndrome score，range of activity， degree of pain，rheumatoid factors，inflammatory factors，bone metabolism，immune function and efficacy of the two groups were evaluated. Results After treatment，compared with those in the western medicine group，TCM syndrome score，DAS28，VAS，RF，IgA，IgG，IgM，CRP，IL ⁃17 and β ⁃CTX level in the combination group were decreased（P < 0.05）. The level of IL⁃10，T⁃P1NP and N⁃MID was increased（P < 0.05）. The total effec⁃ tive rate of the combination group was better（P < 0.05）. Conclusion For patients with RA，after treatment with warm acupuncture combined with Jianpi Tongluo Formula，lower TCM syndrome score and pain degree，re⁃ duced body inflammation，improved immune function and bone metabolism level and improved joint range of the patients are observed，and the clinical effect is remarkable.