Objective To analyze the incidence and death of cervical cancer and the changing trend of disease burden from 2016 to 2021 in Zibo City，and to provide suggestions for the prevention and treatment of cervi⁃ cal cancer. Methods The incidence and mortality data of cervical cancer（ICD ⁃10）in Zibo City from 2016 to 2021 were analyzed，and the indicators of incidence，mortality and disease burden were calculated. Results The incidence rate of cervical cancer in Zibo was increased from 14.77/100 000 in 2016 to 17.54/100 000 in 2021 （APC = 4.51%，t = 3.37，P = 0.028）. The standardized incidence rate was increased from 12.13/100 000 to 14.83/ 100 000（APC = 4.85%，t = 3.92，P = 0.017）. The incidence was increased first and then decreased with age， and peaked in the age group of 45 ~ 54 years. The incidence rate in the 25 ~ 44 years old age group in Yiyuan County was increased from 12.60/100 000 in 2016 to 30.63/100 000 in 2021（APC = 24.73%，t = 3.87，P = 0.018）. The mortality rate of cervical cancer was increased with age. From 2016 to 2021，the YLD rate caused by cervical cancer was increased from 0.72‰ to 0.86‰，and the APC was 4.50%. DALY rate of cervical cancer in urban areas was higher than that of the rural areas. The proportion of YLL rate in DALY rate of cervical cancer in urban and rural areas showed a downward trend，APC were -3.70% and -5.40%，respectively. The proportion of YLD rate in DALY rate caused by cervical cancer in urban and rural areas showed an upward trend，APC was 2.44% and 4.59%，respectively. Conclusion The incidence and mortality of cervical cancer in Zibo city were high，and the incidence and YLD rate showed an increasing trend. The DALY rate caused by cervical cancer in urban area was higher than that of the rural area. It is necessary to further strengthen the prevention and control of cervical cancer.