Cryoablation plays an important role in the treatment of non⁃small cell lung cancer in addition to dehydrating，rupturing and necrotizing tumour cells at low temperature，but also by generating anti⁃tumour immune responses. In recent years，immunotherapy has been effective in the treatment of NSCLC. So is there a synergistic effect between cryoablation and immunotherapy in NSCLC treatment？ This article reviews the application of cryo⁃ therapy，immunotherapy and combination therapy in the treatment of NSCLC.