Mitochondrial quality control system is a key mechanism for maintaining mitochondrial homeo⁃ stasis and function in eukaryotic cells. Cardiomyocytes are the main components of myocardial tissue，and their nor⁃ mal relaxation，contraction，and electrophysiological maintenance are highly dependent on mitochondrial energy metabolism pathway. Recent studies have shown that cardiac senescence is closely related to extensive mitochondri⁃ al damage and dysfunction in cardiomyocytes. Therefore，an imbalance of myocardial mitochondrial quality control system may be a key link leading to cardiac senescence. This article summarizes the potential relationship between mitochondrial quality control mechanism and cardiac aging，and reviews the latest research progress and interven⁃ tion strategies for cardiac aging based on mitochondrial quality control pathway.