Anti⁃tuberculosis drug⁃induced liver injury（ATB⁃DILI）was the most common adverse drug reaction in anti⁃tuberculosis treatment，which was one of the reasons that caused patients to stop anti⁃tuberculosis treatment. It then affectes the therapeutic effect of tuberculosis. This article focuses on the pathogenesis，clinical diagnosis and treatment of ATB ⁃DILI，and the necessity of prevention and liver protection in anti ⁃tuberculosis treatment，