Diabetic foot ulcer is a common complication caused by long⁃term severe diabetes，its pathogen⁃esis is still in the study，in recent years，to explore the mechanism of diabetic foot ulcer wound repair become research hot spots，but the mechanism still is less，the author through reading of diabetic foot ulcer wound repair mechanism at home and abroad，summarized the research progress of Including Exosomes（Exos），Nocth，NF⁃κB，Wnt/β⁃catenin，MAPK，etc.，aiming to provide a new idea for the treatment and mechanism of diabetic foot ulcer wounds.