Objective To explore the risk factors of epilepsy after continuous lumbar cistern drainage in hypertensive cerebral hemorrhage（HICH）patients. Methods According to whether they developed secondary epilepsy or not，the clinical data of 356 HICH patients treated in our hospital from October 2018 to January 2021 were retrospectively evaluated. They were split into the occurrence group（52 cases）and the non⁃occurrence group （304 cases）.Independent risk factors for secondary epilepsy in HICH patients were screened by LASSO and Logistic regression analysis.，and a nomogram prediction model was constructed. The discrimination and calibration curve of the model were evaluated by the receiver operating curve（ROC）. Results Univariate analysis and multivariate logistic regression analysis showed that the course of hypertension，hematoma volume，drainage tube pollution， postoperative rebleeding，tumor necrosis factor ⁃ α（TNF ⁃ α），Interleukin ⁃6（IL ⁃6）and neuron specific enolase （NSE）were independent risk factors of epilepsy after continuous lumbar cistern drainage in HICH patients（P < 0.05）. The verification results show that the c⁃index of the training set and the verification set are 0.880（95% CI： 0.833 ~ 0.921），0.870（95% CI：0.825 ~ 0.922），and the area under the ROC curve（AUC）are 0.884（95% CI： 0.828 ~ 0.941）and 0.869（95% CI：0.790 ~ 0.915）respectively. The nomogram model has strong accuracy，high discrimination，and good fitting. Conclusions Following continuous lumbar cistern drainage in these HICH patients，hypertension course，hematoma volume，drainage tube pollution，postoperative rebleeding，TNF⁃α，IL⁃6， and NSE were independent risk factors for epilepsy（P < 0.05）.