Objective To investigate the correlation of procalcitonin（PCT）and creactive protein（CRP）with sepsis⁃related organ failure assessment（SOFA）and quick sepsis⁃related organ failure assessment（qSOFA）score in sepsis patients as well as the risk factors that affect the prognosis of sepsis patients. Methods The clinicaldata of the patients admitted to the intensive care unit（ICU）of the People′s Hospital of Wudang and The SecondPeople′s Hospital of Guiyang，from January 2016 to June 2020 were retrospectively analyzed. 106 sepsis patientsunderwent PCT and CRP testing，and SOFA and qSOFA scores were evaluated. The patients were divided intosurvival group（n = 82）and death group（n = 24）according to the prognosis. The PCT，CRP，SOFA and qSOFAscore of the two groups were compared. The PCT and CRP values of different SOFA evaluation groups and qSOFAevaluation groups were compared. Spearman correlation analysis was used to analyze the correlationship of PCT andCRP with SOFA and qSOFA. The influencing factors of sepsis were analyzed by regression. Results Comparedwith the survival group，the incidence of drinking and hypertension was higher in the death group. PCT，SOFA andqSOFA scores were significantly increased（P < 0.05）. PCT increased significantly with the increase of SOFA andQ⁃SOFA scores（P < 0.05）. PCT was positively correlated with SOFA and qSOFA scores（r > 0，P < 0.05）. CRPwas not associated with SOFA and qSOFA scores（P > 0.05）. PCT，SOFA and qSOFA scores were risk factors for death in sepsis patients（P < 0.05）. Conclusion Compared with CRP，PCT can better reflect the severity andprognosis of sepsis patients. When PCT is used in combination with SOFA and qSOFA score，it is more beneficialfor clinicians to judge and evaluate the condition.