Objective To investigate the different effects of partial plasma exchange combined with dualplasma molecular adsorption and pure plasma exchange on short⁃term survival rate of patients with acute⁃on⁃chronicliver failure（ACLF）. Methods Data of 53 hospitalized patients with ACLF who received artificial liver therapyincluding 30 treated with dual plasma molecular adsorption combined with partial plasma exchange and 23 withsimple plasma exchange，were retrospectively analyzed. Related serum biochemical indexes and survival rates at the4th and 12th week were compared between the two groups before and after the treatment，and clinical prognosticfactors of ACLF patients were analyzed by univariate analysis. Results Liver function were improved in both groupsafter the treatment，and the difference was statistically significant（P < 0.05）. Cumulative survival rate of the twogroups at the 4th week was 86.96% and 96.67% respectively and the follow⁃up cumulative survival rate at the 12thweek was 86.67% and 69.56% respectively，showing no statistical significance（P > 0.05）. Conclusion Dual plasmamolecular adsorption combined with partial plasma exchange and pure plasma exchange effectively improve therelevant biochemical indexes of patients with ACLF，but they play no significant role in short⁃term survival rate.