Objective To determine the clinical efficacy of arthroscopic double row suture combined with platelet⁃rich plasma in the treatment of full⁃thickness rotator cuff tear. Methods A total of 78 patients with full⁃thickness rotator cuff tear who were admitted to our hospital from June 2019 to June 2020，and underwent arthroscopic double⁃row suture were retrospectively analyzed. All patients were assigned to observation group（platelet⁃ rich plasma，n = 39）and control group（intra⁃articular lavage fluid=39）. VAS scores before operation and at 3， 6，12 and 18 months after operation，Constant and UCLA scores before operation and at 6，12 and 18 months after operation and rotator cuff re ⁃ tear at 12 months after operation were compared between the two groups. Results ANOVA for repeated measurement showed that there were temporal，grouping and interaction effects in the VAS， Constant and UCLA scores of the two groups，and the differences were statistically significant（P < 0.05）. VAS scores in observation group were lower than those in control group at 3 and 6 months after operation，but there was no significant difference at 12 and 18 months after operation（P > 0.05）. Constant and UCLA scores after operation were higher than those before operation. Constant and UCLA scores in observation group were better than those in control group at 6 and 12 months after operation，but there was no significant difference at 18 months after opera⁃ tion（P > 0.05）. At 12 months after operation，MRI results showed that there were 2 cases with re⁃tear in observa⁃ tion group（tear rate 5.1%）and 5 cases with re⁃tear in control group（tear rate 12.8%），and the differences were statistically significant（P > 0.05）. Conclusion Arthroscopic double row suture combined with platelet⁃rich plasma in the treatment of rotator cuff tears was safe，which could significantly reduce postoperative pain，and accelerate the recovery of shoulder joint function in a short time with satisfactory clinical outcomes.