Either endogenous or acquired resistance to chemotherapy has become the main obstacles in the treatment of neuroglioma. As is well ⁃ known，glioma chemoresistance is caused by interaction of multiple mecha⁃ nisms. Therefore，sufficient understanding of potential mechanism on chemoresistance and development of new treatment targets to eliminate chemoresistance are crucial to the prognosis improvement for glioma patients. It is inspiring that more and more evidence has indicated that long non⁃coding RNA（lncRNA）mediated occurrence， development and chemoresistance of glioma via targeting at various regulation mechanisms. This review has systemi⁃ cally clarified the molecular mechanism of lncRNA in the regulation of glioma chemoresistance and has discussed the potential function of lncRNA as a marker of glioma chemoresistance and a novel treatment target. It aims at developing novel research direction for glioma chemoresistance treatment by regulating these specific lncRNAs to reverse chemoresistance of tumor cells.