Objective To understand the epidemiological characteristics of syphilis in Zhaoqing City in the past ten years（2011⁃2020），and provide a scientific basis for preventive interventions. Methods We retro⁃ spectively collected the syphilis registry data in Zhaoqing from 2011 to 2020. Results From 2011 to 2020，a total of 13，119 cases of syphilis were reported in Zhaoqing City，and the incidence of syphilis from 39.18/100 000 to 41.87/100 000 had shown an upward trend，（χ2 = 242.909，P < 0.05）. The staging of syphilis is dominated by latent syphilis，accounting for 86.31%；in the past 10 years，latent syphilis has shown an upward trend，while primary syphilis，secondary syphilis and fetal syphilis have all shown a downward trend，especially with fetal syphilis. Most significantly，the incidence rate decreased from 1.2129/100 000 live births to 1.46/100 000 live births（χ2 = 239.912，P < 0.05）. Moreover，Syphilis is concentrated in the urban region of Zhaoqing city. Both males and females showed a fluctuating upward trend（χ2 = 98.697，161.313，P < 0.05），and the incidence of males was more than that of females，with a sex ratio of 1.19（χ2 = 17.620，P < 0.05）. The incidence tends to increase with age，and the incidence is highest in people over 50 years old，and the incidence in the 10 to 19⁃year⁃old group has an increasing trend in 10 years. Of the total cases，farmers accounted for the highest proportion of occupational distribution，followed by housework and unemployed. Conclusions From 2011 to 2020，the incidence of syphilis in Zhaoqing City showed a slight upward trend，Men，teenagers，and the elderly are the key management targets.