Multidrug⁃resistant tuberculosis（MDR⁃TB）which characterized by high morbidity，high mor⁃ tality，high treatment cost and low cure rate is a huge obstacle to the WHO goal of ending TB globally by 2035. As the the second country with a high burden of MDR⁃TB ，the situation of prevention and control is even more severe. This paper tries to discuss the problems and confusions in the control of MDR ⁃TB from the aspects of diagnosis， treatment，prevention and control strategies，as well as the focus of our desire to make breakthroughs.