Peritoneal dialysis（PD）is one of the main methods of renal replacement therapy because of its advantages in protecting residual renal function. Peritoneal fibrosis caused by long ⁃term peritoneal dialysis is the main reason for PD withdrawal. The strategy of prevention of peritoneal fibrosis is still limited. Many scholars have carried out continuous exploration and research on peritoneal dialysis. We reviewed the recent progress of peritoneal fibrosis in peritoneal dialysis. This paper summarizes the new methods for preventing and treating peritoneal fibrosis in peritoneal dialysis，including inhibiting chronic inflammation，inhibiting peritoneal neovascularization，inhibit⁃ ing the secretion of fibrogenic factors，improving the biocompatibility of peritoneal dialysate，suspending peritoneal dialysis and gene therapy. The purpose is to provide reference for the prevention of peritoneal fibrosis on peritoneal dialysis.