Acute clinical events and adverse prognosis of thromboembolic diseases seriously threaten patients′ life and quality of life. The development of thrombolytic technique has greatly reduced the incidence of thromboembolic events. Compared with traditional drug thrombolysis，surgical thrombectomy and intraductal throm⁃ bolysis，ultrasound combined with targeted microbubble thrombolytic technology has the advantages of wide throm⁃ bolytic time window and accurate thrombolytic drug dose，as well as the thrombolytic effect is significant and easy to evaluate. This article focuses on the preparation and characteristics of targeted microbubbles，the mechanism of ultrasound ⁃assisted thrombolysis mediated by targeted microbubbles，and the research progress of targeted micro⁃ bubbles in experimental and clinical application.