Objective o investigate the relationship between high residual platelet activity and Ⅱb/Ⅲa receptor，P⁃selectin on platelet surface，prognosis in patients with non ST segment elevation acute myocardial infarction（NSTEMI）after percutaneous coronary intervention（PCI）. Methods A total of 214 patients with NSTEMI receiving PCI were selected. According to the platelet aggregation rate，they were divided into HRPR group and LRPR group. The level of Ⅱb/Ⅲa receptor（PAC⁃1）and P⁃selectin（CD62p）on the platelet surface were measured. All patients were followed up for one year to count the occurrence of ischemic events. Results The levels of PAC⁃ 1+ /CD62P+，PAC⁃1- /CD62P+，PAC⁃1+ /CD62P- platelets in HRPR group were higher than those in LRPR group，the difference was statistically significant（P < 0.05）. The platelet aggregation rate was positively correlated with the levels of PAC⁃1+ /CD62P+，PAC⁃1+ /CD62P-（P < 0.05）. When platelets were pre incubated with PAC⁃1，the platelet aggregation rate was decreased significantly（P < 0.05）. When platelets were pre incubated with anti⁃CD62p anti⁃ body，there was no significant change in platelet aggregation rate（P > 0.05）. The incidence of ischemic events in HRPR group was higher than that in LRPR group（P < 0.05）. Conclusion HRPR in NSTEMI patients after PCI was related to Ⅱb/Ⅲa receptor on platelet surface，but it′s not related to P⁃selectin. HRPR could increase the risk of ischemic events in patients.