Abstract:

Objective To investigate the association of DCE⁃MRI quantitative parameters with the degreeof histopathological differentiation and molecular biological marker p53 in patients with rectal cancer. Methods 63 patients with primary rectal cancer were surgically and pathologically confirmed and the expression of p53 wasdetected by immunohistochemistry. All the patients underwent DCE ⁃MRI scan preoperatively. The quantitativeparameters of ROI of tumor site were obtained by image post⁃processing. The association of the quantitative parame⁃ters of DCE⁃MRI with the pathological differentiation of rectal cancer and the expression of p53 was analyzed.Results Ktrans，Kep and Ve values increased with a decrease in tissue differentiation in 63 patients. The differ⁃ences in DCE⁃MRI quantitative parameters of different tissue differentiation were statistically significant（P < 0.05）.Ktrans，Kep，and Ve values were significantly correlated with the degree of pathological differentiation of rectalcancer（P < 0.05）. The differences in Ktrans and Ve among different levels of p53 expression in rectal cancer werestatistically significant（P < 0.05）；Ktrans and Ve were positively correlated with p53 expression（P < 0.05），butKep was not correlated with p53 expression（P > 0.05）. The area under ROC curve（AUC）of Ktrans value was thelargest in predicting p53 expression，with sensitivity of 84.44% and specificity of 83.33% . Conclusions Thequantitative parameters of DCE⁃MRI were correlated with the degree of pathological differentiation and the expres⁃sion level of p53 in rectal cancer.

Key words:

dynamic contrast enhanced MRI, rectal cancer, pathology, p53