Abstract: Objective To analyze the relationship between replication of 2019 novel coronavirus and liver
injury in patients with moderate and severe type of coronavirus infectious disease 2019. MethodsNineteen patients
with coronavirus infectious disease 2019 were admitted to Beijing Youan Hospital，Capital Medical University.
Collect the results of novel coronavirus nucleic acids from respiratory specimens of patients such as sputum and
throat swabs. The changes of alanine aminotransferase （ALT），aspartate aminotransferase （AST） and total
bilirubin（TBil）indexes in patients with different clinical types were collected. The research data were analyzed
using SPSS 22.0 statistical software. Differences between groups were analyzed using Fisher′s exact chi⁃square test.
Results There were 13 cases of moderate type（56.5%），6 cases of severe type（26.1%），aged 31 to 71 years，
the median age was 60 years；7 cases of males（36.8%），and 12 cases of female（63.2%）. ALT was increased in
12（63.2%%）of 19 patients，AST was increased in 10（52.6%），TBil was high in 2（10.5%），there was no statistical
difference in the proportion of ALT，AST and TBil during the period of nucleic acid positive and nucleic acid nega⁃
tive（P > 0.05）. Conclusions Patients with moderate and severe types of COVID⁃19 will have abnormal elevation
of liver biochemical indexes，such as ALT，AST，TBIL and the main increase is transient. The direct toxicity of
novel coronavirus is less likely to cause liver damage.

Key words: SARS?CoV?2, COVID?19, nucleic acid, liver function, liver injury