Abstract:

Gap junction（GJ）is a special cell membrane structure composed of connexin protein（Cx）. The exchange of material and energy between adjacent cells through GJ is called gap junction cell communication （GJIC）. Junction protein connexin 43（Cx43）is the main junction protein involved in the formation of GJIC. The serine and proline rich in Carboxyl terminal（CT）at the end of its carboxy group are potential targets for Cx43 phosphorylation modification，and important domains of protein interaction. The phosphorylation of Cx43 carboxy terminal regulates the transport of Cx43，the assembly and degradation of GJ，and the gating of GJ channel，which is very important to regulate GJIC in neurous system. This review summarizes the current understanding of Cx43 carboxy terminal phosphorylation modification and the effect of Cx43 phosphorylation modification on GJIC，and provides feasible ideas for further research in cerebral ischemia.

Key words:

Cx43, carboxy terminal, phosphorylation modification, gap junction communication, cerebral ischemia