Abstract:

Objective To investigate the influencing factors of indeterminate response（IDR）in patients with differentiated thyroid cancer（DTC）after 131I treatment. Methods A retrospective analysis was performed on 127 patients with DTC who received 131I ablation in the Department of Nuclear Medicine，the First Affiliated Hospital of University of Science and Technology of China from June 2017 to June 2020. According to the treatment response evaluation system，the treatment effect was divided into two groups：ER group：excellent treatment response（ER）（n = 81）and IDR group：indeterminate response（IDR）（n = 46）. Univariate analysis was per⁃ formed by t⁃test and χ2 test，and then factors with P < 0.05 were included in Logistic regression analysis to identify the influencing factors of IDR. Results IDR occurred in 46 patients after treatment with 131I. Single factor analysis showed that there were no significant differences between two groups in gender，age，TSH，maximum size of the tumor et al，while preablative⁃stimulated thyroglobulin，the time interval of 131I therapy and surgery and TgAb was statistically significant（all P < 0.05）. Logistic regression analysis showed that ps⁃Tg ≥ 2.0 ng/mL was an indepen⁃ dent influencing factor of IDR（P < 0.001），and there were no statistically significant differences in the time inter⁃ val of 131I therapy and surgery and TgAb. The Kaplan⁃Meier estimate for IDR showed that the response of patients in the ps⁃Tg（≥ 2.0 ng/mL）group was poorer than that of those in the ps⁃Tg（＜2.0 ng/mL）group. Conclusion Ps⁃Tg is an independent influencing factor for IDR after 131I treatment.

Key words:

thyroid cancer, 131I treatment, indeterminate response