Objective To observe the efficacy of preventive oral gabapentin on postoperative analgesia and recovery in patients undergoing laparoscopic radical resection of colorectal cancer. Methods 43 patients in⁃ cluding 27 males and 16 females with colorectal cancer were collected in the Department of Anesthesiology，Gener⁃ al Hospital of Southern Theater Command of PLA from May 2019 to October 2019，and randomly assigned into rou⁃ tine analgesia group（group R）and gabapentin group（group G）. Group G patients received two doses（600 mg each）of gabapentin and PCIA orally the night before the operation and the morning of the operation，whereas group R patients received only PCIA. The VAS（visual analogue score），patient pain satisfaction，and postopera⁃ tive opioids consumption before discharge，the 15⁃item quality of recovery（QoR⁃15），incidences of postoperative nausea and vomiting（PONV），Ramsay sedation score，intraoperative remifentanil and propofol consumption，and cardiovascular response during endotracheal intubation were all recorded at 1，2，3，4，6，12，24，48 and 72 hours after the operation. Results The VAS in group G were statistically lower than that in group R at rest and coughing 10 days after the operation，and on movement 9 days after the operation（P<0.05）. Meanwhile，in group G，pain satisfaction scores were statistically higher than in group R at 9 days after surgery and QoR⁃15 scores at 12 days after surgery（P < 0.05）. Moreover，when compared to group R，group G had statistically lower postoperativetotal opioid use，intraoperative remifentanil consumption，cardiovascular response during endotracheal intubation， and incidences of remedial antiemetics（P < 0.05）. There was no significant difference in total propofol dosage be⁃ tween the two groups（P > 0.05）. Conclusions In colorectal cancer patients undergoing laparoscopic radical re⁃ section，preoperative prophylactic oral gabapentin can significantly reduce the VAS scores before discharge and the total consumption of opioids after surgery，and improve patient satisfaction with analgesia and postoperative rehabil⁃ itation quality.