The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (8): 1080-1083.doi: 10.3969/j.issn.1006⁃5725.2021.08.024

• Review • Previous Articles     Next Articles

Research progress of 1，25⁃（OH）2D3 in airway inflammation and airway remodeling

YANG Shenghong，YAO Peixue，OU Yingyong，OUYANG Yao.   

  1. Department of PCCM and Critical Care Medicine Respiratory，Affiliated Hospital of Zunyi Medical University，Zunyi 563000，China

  • Online:2021-04-25 Published:2021-04-25
  • Contact: OUYANG Yao E⁃mail：ouyangyao116@sohu.com

Abstract:

1，25⁃（OH）2D3，the active form of Vit D，plays an important role in airway inflammation and remodeling.due to its anti⁃inflammatory and antifibrosis effects.1，25 ⁃（OH）2D3 plays an anti⁃inflammatory role in airway by reducing inflammatory factors，inducing the release of antimicrobial peptides and binding to Vit D recep⁃ tor.At the same time 1，25⁃（OH）2D3 can reduce airway epithelial fibrosis and affect the proliferation and secretion of airway cells such as airway smooth muscle cells，airway epithelial cells and airway fibroblasts. In addition，1，25 ⁃（OH）2D3 decreased the expression of TGF⁃β1 and IL⁃17A. This article reviews the research of 1，25⁃（OH）2D3 in airway inflammation and airway remodeling.

 

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