基于肠道菌群理论探讨益生菌联合运动康复在帕金森病患者中的疗效

doi:10.3969/j.issn.1006-5725.2025.20.007

Abstract

Abstract:

Objective To investigate the effects of gut microbiota regulation combined with exercise rehabilitation on non-motor symptoms and neurological function in Parkinson's disease patients. Methods A total of 154 Parkinson's disease patients admitted to our hospital from January 2022 to January 2024 were selected as the subjects of the study. Using a random number table， these 154 patients were evenly divided into a control group and a treatment group， with 77 patients in each group. Both groups received standard treatments， but the control group also underwent exercise rehabilitation therapy， while the treatment group received probiotic supplementation and exercise rehabilitation therapy. The effectiveness of the two groups was then compared. Results Following the 12 weeks， 24 weeks therapeutic regimen， The treatment group showed significantly better outcomes （P < 0.05）.Clinically meaningful reductions were observed in Hoehn-Yahr staging， alongside decreased scores on standardized instruments assessing psychiatric symptoms HAMA， HAMD， SCOPA-AUT， UPDRS Ⅰ-IV and PDSS （P < 0.05）.Concurrently， the study group exhibited enhanced MMSE （P < 0.05）. Fecal microbiome analyses revealed a favorable ecological shift characterized by increased colonization of beneficial genera Bifidobacterium and Lactobacillus， with concomitant suppression of pathobionts Enterococcus and Enterobacteriaceae.Gait analysis revealed increased step length， speed， and frequency in the treatment group （P < 0.05）. Conclusion Patients with Parkinson's disease who received probiotics combined with exercise rehabilitation treatment could effectively improve non-motor symptoms and neurological function， while promoting the balance of intestinal flora， and reduce clinical symptoms.

Key words: intestinal flora, exercise rehabilitation, Parkinson's disease, non-motor symptoms, neurological function

CLC Number:

R742

Jie YANG,Shukun DENG,Peng YUAN,Yachen SHI,Xuemei MA,Min. SU. The efficacy of probiotics combined with exercise rehabilitation in Parkinson's disease patients was investigated based on the theory of intestinal flora[J]. The Journal of Practical Medicine, 2025, 41(20): 3191-3197.

Figures/Tables 8

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References 28

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组别	例数	性别（男/女）/例	年龄/岁	病程/年
对照组	77	45/32	67.38 ± 5.24	3.59 ± 0.26
研究组	77	43/34	67.81 ± 5.78	3.56 ± 0.16
χ²/t值		0.092	0.483	0.862
P值		0.761	0.629	0.389

分级	定义
0	无症状
1	单侧患病
1.5	单侧患病，对躯干中轴肌肉有影响；或另外一侧躯体可疑受累
2	双侧患病，未损害平衡
2.5	轻度双侧患病，姿势反射稍差，但是能自行纠正
3	双侧患病，有姿势平衡障碍，后拉试验阳性
4	严重残疾，仍可独自站立或行走
5	不能起床，或生活在轮椅上

时间	例数	1级	1.5级	2级	2.5级	3级
治疗前
对照组	77	4（5.19）	9（11.69）	12（15.58）	27（35.06）	25（32.47）
研究组	77	3（3.90）	10（12.99）	19（24.68）	25（32.47）	20（25.97）
U值		0.974
P值		0.330
治疗12周
对照组	77	5（6.49）	15（19.48）	12（15.58）	25（32.47）	20（25.97）
研究组	77	10（12.99）	16（20.78）	22（28.57）	15（19.48）	14（18.18）
U值		2.080
P值		0.037
治疗24周
对照组	77	7（9.09）	17（22.08）	14（18.18）	26（33.77）	13（16.88）
研究组	77	12（15.58）	18（23.38）	25（32.47）	18（23.38）	4（5.19）
U值		2.473
P值		0.013

组别	例数	步长/cm			步频/min			步速/（cm/min）
组别	例数	治疗前	治疗12周	治疗24周	治疗前	治疗12周	治疗24周	治疗前	治疗12周	治疗24周
对照组	77	40.59 ± 8.54	56.79 ± 3.66^*	60.48 ± 3.31^*#	89.29 ± 16.25	75.96 ± 6.45^*	79.01 ± 4.23^*#	60.84 ± 15.92	74.49 ± 3.91^*	78.91 ± 4.33^*#
研究组	77	40.54 ± 8.57	65.49 ± 4.32^*	69.93 ± 4.53^*#	89.48 ± 16.36	78.39 ± 3.26^*	82.94 ± 3.55^*#	60.81 ± 15.77	77.71 ± 3.75^*	81.95 ± 3.64^*#
t值		0.036	13.483	14.780	0.072	2.950	6.244	0.011	5.215	4.715
P值		0.971	<0.001	< 0.001	0.942	0.003	< 0.001	0.990	< 0.001	< 0.001

The efficacy of probiotics combined with exercise rehabilitation in Parkinson's disease patients was investigated based on the theory of intestinal flora

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