NLRP3炎性小体水平联合ECP/MPO比值预测慢性鼻窦炎鼻内镜术后复发的临床价值

doi:10.3969/j.issn.1006-5725.2024.22.013

Abstract

Abstract:

Objective To explore the clinical value of NOD-like receptor pyrin domain-containing protein 3 （NLRP3） inflammasome levels combined with eosinophil cationic protein （ECP）/myeloperoxidase （MPO） ratio in predicting the recurrence of chronic rhinosinusitis after endoscopic sinus surgery. Methods 205 patients with chronic sinusitis who received treatment from the hospital from February 2018 to December 2022 after endoscopic sinus surgery were selected for prospective analysis. The patients were divided into non-recurrence group and recurrence group according to whether they relapsed one year after surgery.The factors influencing the recurrence of patients with chronic sinusitis after endoscopic sinus surgery were screened， and the predictive efficacy was evaluated by receiver operating characteristic curve （ROC）. Results The NLRP3 inflammasome level， ECP/MPO ratio， sinus CT score， Lund-Kennedy score and immunoglobulin E in the relapsing group were higher than non-relapsing group （P < 0.05）. NLRP3 inflammasome level， ECP/MPO ratio， sinus CT score， Lund-Kennedy score and immunoglobulin E were the influencing factors of postoperative recurrence in patients with chronic sinusitis （P < 0.05）. The area under the curve （AUC） values of NLRP3 inflammasome level， ECP/MPO ratio and combined prediction of postoperative recurrence in patients with chronic sinusitis were 0.823， 0.815 and 0.899， respectively （P < 0.05）， and the AUC value of combined NLRP3 was higher （P < 0.05）. Conclusion NLRP3 inflammasome level combined with ECP/MPO ratio has a high value in predicting the risk of recurrence after nasal endoscopy.

Key words: sinusitis, NOD-like receptor heat protein domain associated protein 3, eosinophilic cationic protein, myeloperoxidase, nasal endoscopy, recurrence, predictive value

CLC Number:

R765.4⁺1

Juanjuan FENG,Zexing CHENG,Lu XIAO. The clinical value of NLRP3 inflammasome level combined with ECP/MPO ratio in predicting the recurrence of chronic sinusitis after endoscopic sinus surgery[J]. The Journal of Practical Medicine, 2024, 40(22): 3196-3201.

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References 33

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组别	例数	NLRP3炎性小体	ECP/MPO比值
非复发组	123	9.27 ± 1.79	0.70 ± 0.18
复发组	78	17.42 ± 3.61	2.31 ± 0.34
t值		21.271	43.767
P值		0.000	0.000

组别	例数	年龄（岁）	性别/［例（%）］		吸烟史/［例（%）］	病程/年	BMI/（kg/m²）	手术时间/［例（%）］
组别	例数	年龄（岁）	男	女	吸烟史/［例（%）］	病程/年	BMI/（kg/m²）	≥ 2 h	< 2 h
非复发组	123	59.81 ± 12.57	76（61.79）	47（38.21）	41（33.33）	5.43 ± 0.44	24.19 ± 2.43	57（46.34）	66（53.66）
复发组	78	60.43 ± 12.88	50（64.10）	28（35.90）	25（32.05）	5.39 ± 0.46	24.31 ± 2.52	34（43.59）	44（56.41）
t/χ²值		0.338	0.109		0.036	0.617	0.336	0.146
P值		0.736	0.741		0.850	0.538	0.737	0.703

影响因素	b	S_b	Wald χ²	P值	OR	95%CI
NLRP3炎性小体水平	1.368	0.371	13.596	< 0.001	3.927	1.727 ~ 8.934
ECP/MPO比值	1.205	0.343	12.342	< 0.001	3.337	1.467 ~ 7.590
鼻窦CT评分	1.053	0.378	7.760	< 0.001	2.866	1.260 ~ 6.520
Lund-Kennedy 评分	1.138	0.446	6.511	< 0.001	3.121	1.372 ~ 7.099
免疫球蛋白E	1.424	0.507	7.889	< 0.001	4.154	1.826 ~ 9.449

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The clinical value of NLRP3 inflammasome level combined with ECP/MPO ratio in predicting the recurrence of chronic sinusitis after endoscopic sinus surgery

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