Abstract:

Objective To study the expression and significance of UFC1 in diffuse large B cell lymphoma （DLBCL）. Methods The expression of UFC1 in DLBCL was detected by immunohistochemical method. The expression of UFC1 in DLBCL was studied by GEPIA and GEO DataSet. The relationship between UFC1 expression and the clinical characteristics of DLBCL was analyzed by GEO DataSet. The relationship between UFC1 expression and DLBCL prognosis was analyzed using GEO Dataset and OSdbl. Linkedomics was used to analyze UFC1 co⁃expressed genes. String⁃db was used to analyze the protein network of UFC1 interaction. Results Immunohisto⁃ chemical results showed that the expression of UFC1 in DLBCL was significantly higher than that of reactive lymph⁃ adentis tissue（P = 0.000），GEPIA analysis showed that the expression of UFC1 in DLBCL was significantly higher than that of normal tissue（P < 0.01），and GSE9327 Dataset analysis also showed that UFC1 was highly expressed in DLBCL（P < 0.000 1）. GSE10846 Dataset analysis showed that high expression of UFC1 was associated with old age（P = 0.003）and non ⁃GCB typing（P = 0.015），and the OS of DLBCL patients with high expression of UFC1 was shorter（P = 0.032 6），while OSdlc analysis showed that PFS（P = 0.015 9）and OS（P = 0.032 5）of DLBCL patients were poor with high expression of UFC1.Linkedomics analysis showed that UFC1 was related to ribosome and oxidative phosphorylation and other tumor mechanisms.String⁃db analysis shows that UFC1 interacts with a variety of tumor markers. Conclusion The expression of UFC1 is increased in DLBCL，and the abnormal high expression of UFC1 is more obvious in the elderly and non⁃GCB type DLBCL. The high expression of UFC1 in 

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