Wnt信号通路与神经管畸形关联性研究进展

doi:10.3969/j.issn.1006-5725.2024.11.022

Abstract

Abstract:

Neural tube defects are a common neurodevelopmental disease， which can be divided into open and closed types. The main symptoms are anencephaly， encephalocele and cranial spina bifida. The relationship between Wnt signaling and neurogenesis has been a popular area in recent years. The Wnt signaling pathway includes Wnt/β-catenin， planar polar cell pathway and Wnt/Ca²⁺ pathway， which plays an important role in neural tube development. This article reviews the current state of research on the Wnt signaling pathway and elucidates the role it plays in the process of neural tube closure， providing insights for the development of drugs related to the prevention and treatment of neural tube defects.

Key words: neural tube defects, Wnt/β-catenin pathway, planar cell polarity pathway, Wnt/Ca²⁺ pathway

CLC Number:

R748

Min HU,Yi RU,Liangqi XIE,Zhi CHAI,Huijie. FAN. Research progress on the relationship between Wnt signaling pathway and neural tube defects[J]. The Journal of Practical Medicine, 2024, 40(11): 1597-1601.

References 34

1	SALAZAR-REVIAKINA A， SIERRA-BRETóN M， RUMBO J， et al. Characterization of Risk Factors for Neural Tube Defects： A Case-Control Study in Bogota and Cali， Colombia， 2001-2018 ［J］. J Child Neurol， 2021， 36（7）： 509-516. doi:10.1177/0883073820981514 doi: 10.1177/0883073820981514
2	KIM T W， PIAO J， KOO S Y， et al. Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use ［J］. Cell Stem Cell， 2021， 28（2）： 343-355.e5. doi:10.1016/j.stem.2021.01.005 doi: 10.1016/j.stem.2021.01.005
3	MARTIN M， VERMEIREN S， BOSTAILLE N， et al. Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders ［J］. Science， 2022， 375（6582）： eabm4459. doi:10.1126/science.abm4459 doi: 10.1126/science.abm4459
4	CLEVERS H， NUSSE R. Wnt/β-catenin signaling and disease ［J］. Cell， 2012， 149（6）： 1192-205. doi:10.1016/j.cell.2012.05.012 doi: 10.1016/j.cell.2012.05.012
5	YU F， YU C， LI F， et al. Wnt/β-catenin signaling in cancers and targeted therapies ［J］. Signal Transduct Target Ther， 2021， 6（1）： 307. doi:10.1038/s41392-021-00701-5 doi: 10.1038/s41392-021-00701-5
6	CHEN Y， CHEN Z， TANG Y， et al. The involvement of noncanonical Wnt signaling in cancers ［J］. Biomed Pharmacother， 2021， 133： 110946. doi:10.1016/j.biopha.2020.110946 doi: 10.1016/j.biopha.2020.110946
7	LÓPEZ-ESCOBAR B， CARO-VEGA J M， VIJAYRAGHAVAN D S， et al. The non-canonical Wnt-PCP pathway shapes the mouse caudal neural plate ［J］. Development， 2018， 145（9）：dev157487.
8	ZHEN H， DENG H， SONG Q， et al. The Wnt/Ca（2+） signaling pathway is essential for the regeneration of GABAergic neurons in planarian Dugesia japonica ［J］. FASEB J， 2020， 34（12）： 16567-16580. doi:10.1096/fj.201903040rr doi: 10.1096/fj.201903040rr
9	GAO J， LIAO Y， QIU M， et al. Wnt/β-Catenin Signaling in Neural Stem Cell Homeostasis and Neurological Diseases ［J］. Neuroscientist， 2021， 27（1）： 58-72. doi:10.1177/1073858420914509 doi: 10.1177/1073858420914509
10	丁芮，周鹏，王翔，等. 基于Wnt5a/Ca~（2+）/NFAT信号通路研究小陷胸汤调控Ca~（2+）载量抑制MGC-803细胞侵袭迁移和上皮间质转化作用［J］. 中国实验方剂学杂志， 2022， 28（12）： 1-11.
11	WANG H， ZHANG R， WU X， et al. The Wnt Signaling Pathway in Diabetic Nephropathy ［J］. Front Cell Dev Biol， 2021， 9： 701547. doi:10.3389/fcell.2021.701547 doi: 10.3389/fcell.2021.701547
12	SUTTON G， KELSH R N， SCHOLPP S. Review： The Role of Wnt/β-Catenin Signalling in Neural Crest Development in Zebrafish ［J］. Front Cell Dev Biol， 2021， 9： 782445. doi:10.3389/fcell.2021.782445 doi: 10.3389/fcell.2021.782445
13	GANDHI S， HUTCHINS E J， MARUSZKO K， et al. Bimodal function of chromatin remodeler Hmga1 in neural crest induction and Wnt-dependent emigration ［J］. Elife， 2020， 9：e57779. doi:10.7554/elife.57779 doi: 10.7554/elife.57779
14	李霞，赵声波，毕先云，等. PAX3基因新突变致Ⅰ型Waardenburg综合征家系基因型与表型特征分析［J］. 临床耳鼻咽喉头颈外科杂志， 2021， 35（7）： 621-626.
15	赵拴平，金海，徐磊，等. 牛PAX3基因结构分析及蛋白功能预测［J］. 中国草食动物科学， 2021， 41（5）： 8-11. doi:10.3969/j.issn.2095-3887.2021.05.002 doi: 10.3969/j.issn.2095-3887.2021.05.002
16	PALMER A J， SAVERY D， MASSA V， et al. Genetic interaction of Pax3 mutation and canonical Wnt signaling modulates neural tube defects and neural crest abnormalities ［J］. Genesis， 2021， 59（11）： e23445. doi:10.1002/dvg.23445 doi: 10.1002/dvg.23445
17	ZHAO T， MCMAHON M， REYNOLDS K， et al. The role of Lrp6-mediated Wnt/β-catenin signaling in the development and intervention of spinal neural tube defects in mice ［J］. Dis Model Mech， 2022， 15（6）：dmm049517. doi:10.1242/dmm.049517 doi: 10.1242/dmm.049517
18	XIANG Y， ZHAO Q， WANG N， et al. Association of Obesity with the Risk of Hyperhomocysteinemia among the Chinese Community Residents： A Prospective Cohort Study in Shanghai， China ［J］. Nutrients， 2021， 13（10）：3648. doi:10.3390/nu13103648 doi: 10.3390/nu13103648
19	PIZZORUSSO T， TOGNINI P. Interplay between Metabolism， Nutrition and Epigenetics in Shaping Brain DNA Methylation， Neural Function and Behavior ［J］. Genes （Basel）， 2020， 11（7）：742. doi:10.3390/genes11070742 doi: 10.3390/genes11070742
20	LIU Y S， GU H， HUANG T C， et al. miR-322 treatment rescues cell apoptosis and neural tube defect formation through silencing NADPH oxidase 4 ［J］. CNS Neurosci Ther， 2020， 26（9）： 902-912. doi:10.1111/cns.13383 doi: 10.1111/cns.13383
21	LI X， ZHOU W， LI X， et al. SOX19b regulates the premature neuronal differentiation of neural stem cells through EZH2-mediated histone methylation in neural tube development of zebrafish ［J］. Stem Cell Res Ther， 2019， 10（1）： 389. doi:10.1186/s13287-019-1495-3 doi: 10.1186/s13287-019-1495-3
22	WENG S， HUEBNER R J， WALLINGFORD J B. Convergent extension requires adhesion-dependent biomechanical integration of cell crawling and junction contraction ［J］. Cell Rep， 2022， 39（4）： 110666. doi:10.1016/j.celrep.2022.110666 doi: 10.1016/j.celrep.2022.110666
23	BUTLER M T， WALLINGFORD J B. Planar cell polarity in development and disease ［J］. Nat Rev Mol Cell Biol， 2017， 18（6）： 375-388. doi:10.1038/nrm.2017.11 doi: 10.1038/nrm.2017.11
24	SHINDO A. Models of convergent extension during morphogenesis ［J］. Wiley Interdiscip Rev Dev Biol， 2018， 7（1）：e293. doi:10.1002/wdev.293 doi: 10.1002/wdev.293
25	BAILLY E， WALTON A， BORG J P. The planar cell polarity Vangl2 protein： From genetics to cellular and molecular functions ［J］. Semin Cell Dev Biol， 2018， 81： 62-70. doi:10.1016/j.semcdb.2017.10.030 doi: 10.1016/j.semcdb.2017.10.030
26	GALEA G L， NYCHYK O， MOLE M A， et al. Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos ［J］. Dis Model Mech， 2018， 11（3）：dmm032219.
27	LIU Y， DONG L， ZHI X， et al. Single nucleotide polymorphisms of PCP pathway related genes participate in the occurrence and development of neural tube defect ［J］. Mol Genet Genomic Med， 2023， 11（1）： e2094. doi:10.1002/mgg3.2094 doi: 10.1002/mgg3.2094
28	WANG Y， CHANG H， RATTNER A， et al. Frizzled Receptors in Development and Disease ［J］. Curr Top Dev Biol， 2016， 117： 113-139. doi:10.1016/bs.ctdb.2015.11.028 doi: 10.1016/bs.ctdb.2015.11.028
29	JAMUAR S S， WALSH C A. Somatic mutations in cerebral cortical malformations ［J］. N Engl J Med， 2014， 371（21）： 2038. doi:10.1056/nejmc1411784 doi: 10.1056/nejmc1411784
30	田甜. 平面细胞极化信号通路基因拷贝数变异和体细胞突变与神经管缺陷［D］. 北京：北京大学医学部， 2021.
31	JOSHI B， GAUR H， HUI S P， et al. Celsr family genes are dynamically expressed in embryonic and juvenile zebrafish ［J］. Dev Neurobiol， 2022， 82（2）： 192-213. doi:10.1002/dneu.22868 doi: 10.1002/dneu.22868
32	CHEN Z， LEI Y， CAO X， et al. Genetic analysis of Wnt/PCP genes in neural tube defects ［J］. BMC Med Genomics， 2018， 11（1）： 38. doi:10.1186/s12920-018-0355-9 doi: 10.1186/s12920-018-0355-9
33	BUTLER M T， WALLINGFORD J B. Spatial and temporal analysis of PCP protein dynamics during neural tube closure ［J］. Elife， 2018， 7：e36456. doi:10.7554/elife.36456 doi: 10.7554/elife.36456
34	LIU L， LIU W， SHI Y， et al. DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway ［J］. J Genet Genomics， 2020， 47（6）： 301-310. doi:10.1016/j.jgg.2020.06.003 doi: 10.1016/j.jgg.2020.06.003

Research progress on the relationship between Wnt signaling pathway and neural tube defects

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