The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (5): 564-571.doi: 10.3969/j.issn.1006⁃5725.2023.05.007

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Comparative analysis of basic clinical features of intrapulmonary and extrapulmonary small cell carcinoma

XIONG Yan*，CHEN Haiwen，NIU Yuchun，ZHANG Jiexia.   

  1. The First Affiliated Hospital of Guangzhou Medical University，Guangzhou Institute of Respiratory Health，Guangzhou 510120，China

  • Online:2023-03-10 Published:2023-03-10
  • Contact: ZHANG Jiexia E⁃mail：drzjxcn@126.com

Abstract:

Objective Collect case data of patients with small cell carcinoma，including Sex，age， ethnicity，tumor primary site，stage，and survival time，compare and analyze the differences in case characteristics and survival outcomes betweenSCLC andEPSCC to better understand the basic clinical features of thetwo groups. Methods SEER stat software was used to extract SEER database of 112415 cases of small cell carcinoma from 1975 to 2016，including sex，age，ethnicity，tumor primary site，Staging and survival time.Categorical variables are described by n（%），Chi ⁃ square test analyzes the correlation between categorical variables. The Kaplan ⁃ Meier method calculated 5⁃year survival and median survival. Univariate and multivariate COX regression analysis affects factors related to survival. Results A total of112415 patients with small cell carcinoma were collected，including 107165（95.3%）in the lung and 5250（4.7%）in the extrapulmonary area. Among the EPSCC，the primary ones in the urinary system and digestive system accounted for the largest proportion，accounting for 1.5% and 1.4%. Survival analysis showed that the 5⁃year survival rate of EPSCC was much higher than SCLC（P < 0.001），Among EPSCC， the 5 ⁃ year survival rate of head and neck small cell carcinoma was the highest，reaching 28.6% ；followed by uterusandovaries with 27%and 26%；respectively，and the lowest in pancreas，appendix and liver at only 4.3%，0% and 0%. COX multivariate regression analysis showed that sex，age，ethnicity，primary site of tumor and whether surgery and/or chemoradiotherapy were all important factors of survival（P < 0.05）. Conclusion The number ofpatients with SCLC was much higher than that of patients with EPSCC（95.3% vs 4.7%），but SCLC had a lower 5⁃ year survival rate than EPSCC（5.4% vs 17.1%）. In patients with EPSCC，small cell carcinoma primary in the head and neck had the highest 5⁃year survival rate（28.6%），while 5⁃year survival was lowest for the liver and appendix （0%），even lower than SCLC（5.4%）.

Key words:

SCLC, EPSCC, surveillance, epidemiology and results database（SEER）