Abstract:

Objective To investigate the effect of ulinastatin combined with Shenmai Injection on myocar⁃ dial injury protection and pulmonary function in patients with severe pneumonia. Methods One hundred and twenty patients with severe pneumonia were randomly divided into control group and observation group，with 60 cases in each group. The control group was treated with Shenmai injection，and the observation group was treated with ulina⁃ statinand for Shenmai injection 2 consecutive weeks. The clinical efficacy，inflammatory factors，myocardial indexes， blood gas indexes and Apache⁃Ⅱ score were compared between the two groups. Results After treatment，the total effective rate of the observation group was higher than that of the control group（P < 0.05）. Compared with those before treatment，FEV1% and FEV1/FVC in the two groups increased after treatment，and FEV1/FVC in the observation group was higher than that in the control group（all P < 0.05），but there was no significant difference between the two groups（P > 0.05）. After treatment，TNF⁃α，CRP and PCT were reduced in the two groups，which were lower in the observation group than those in the control group（P < 0.05）；CK ⁃MB，LDH，α⁃HBDE，NT ⁃ proBNP and cTnⅠin the observation group were lower than those in the control group（all P < 0.05）；PaO2，SaO2 and OI in the two groups were higher than those before treatment，which were higher in the observation group（all P < 0.05）；the Apache Ⅱ score of the two groups was lower than that before treatment，and that of the observation group was lower than that of the control group（all P < 0.05）. The incidence of adverse reactions such as vascular pain，diarrhea and skin pruritus in the observation group was significantly lower than that in the control group （all P < 0.05）. Conclusion Shenmai injection combined with ulinastatin can significantly reduce the pulmonary inflammatory state of patients with severe pneumonia，improve blood gas and protect damaged myocardium. It has good curative effect and less adverse reactions.

Key words:

severe pneumonia, ulinastatin, Shenmai Injection, inflammatory factors, myocardial protection, blood gas