间充质干细胞在急性髓系白血病骨髓微环境中的研究进展

doi:10.3969/j.issn.1006-5725.2025.02.021

Abstract

Abstract:

Acute myeloid leukemia （AML） is a highly heterogeneous hematological malignancy， driven by multiple gene mutations and characterized by high incidence and mortality rates. Mesenchymal stem cells （MSCs）， which possess self?renewal and multidirectional differentiation potentials， play crucial roles within the bone marrow microenvironment. Emerging research has demonstrated that MSCs contribute to AML development through various mechanisms， including mitochondrial transfer， transmission of extracellular vesicles， adipogenic differentiation， and secretion of pro?cancer proteins. This review provides a comprehensive summary of the involvement of MSCs in the AML bone marrow microenvironment and offers insights for developing novel therapeutic strategies targeting MSCs in AML treatment.

Key words: acute myeloid leukemia, mesenchymal stem cell, bone marrow microenvironment, cancer-promoting effect, targeted therapy

CLC Number:

R733

Xingyu WAN,Nan LI,Shuiqing LIU,Xi. ZHANG. Research advances of mesenchymal stem cells in the bone marrow microenvironment of acute myeloid leukemia[J]. The Journal of Practical Medicine, 2025, 41(2): 294-299.

Figures/Tables 5

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References 51

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研究团队	EVs来源	促癌/抑癌	作用机制	下游基因或通路	对AML的影响
WU等^［13］	AML患者MSCs	促癌	传递miR?10a	RPRD1A, Wnt/β?catenin	促进细胞增殖，避免细胞凋亡，降低化疗敏感性
JI等^［14］	AML患者MSCs	促癌	传递miR?26a?5p	GSK3β, Wnt/β?catenin	促进细胞增殖，促进迁移侵袭
CHENG等^［15］	正常MSCs细胞株	抑癌	传递miR?23b?5p	TRIM14, PI3K/AKT	抑制细胞增殖，诱导细胞凋亡
ZHANG等^［16］	正常MSCs细胞株	抑癌	传递miR?222?3p	IRF2, INPP4B	抑制细胞增殖，诱导细胞凋亡
XU等^［17］	正常MSCs细胞株	抑癌	传递hsa?miR?124?5p	SMC4	抑制细胞增殖，阻断细胞周期，诱导细胞凋亡
SUN等^［18］	正常脐带血MSCs	抑癌	传递NE	p38 MAPK?STAT3	阻断细胞周期，诱导细胞凋亡，促进细胞分化

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Research advances of mesenchymal stem cells in the bone marrow microenvironment of acute myeloid leukemia

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