创伤后应激障碍患者小脑灰质髓鞘变化与认知功能的关系

doi:10.3969/j.issn.1006-5725.2025.14.009

Abstract

Abstract:

Objective To explore the differences in cerebellar gray matter myelin content and gray matter volume between patients with post-traumatic stress disorder （PTSD） and healthy controls （HC） using the ratio of T1-weighted （T1w） and T2-weighted （T2w） images and voxel-based morphometry （VBM） analysis， and to examine the correlation of these differences with cognitive function. Methods A total of 30 PTSD patients and 30 healthy controls （HC） matched for age， gender， and education level were included in this study. Cognitive function was assessed using the Montreal Cognitive Assessment （MoCA）， and magnetic resonance imaging （MRI） scans were performed for both groups. Two-sample t-tests were used to analyze the group differences in cerebellar gray matter region T1w/T2w ratios and gray matter volume. Spearman partial correlation analysis was used to explore the correlation between the intergroup differences and cognitive function. Results Compared to the HC group， the PTSD group showed a reduced left cerebellar gray matter T1w/T2w ratio （voxel level P < 0.001， cluster level P < 0.05， GRF corrected）. The areas with decreased T1w/T2w ratio in the PTSD group also exhibited reduced gray matter volume （voxel P < 0.005， cluster P < 0.05， GRF corrected）. Correlation analysis revealed a positive correlation between the left cerebellar gray matter T1w/T2w ratio and the severity of cognitive impairment in the PTSD group. Conclusions The PTSD group exhibited reduced myelin content and gray matter volume in the left cerebellar gray matter region， with both myelin reduction and volume loss positively correlating with the severity of cognitive impairment. The T1w/T2w ratio provides a new perspective for studying myelination in PTSD patients.

Key words: post-traumatic stress disorder, T1w/T2w, myelin sheath, cerebellum, gray matter volume, cognitive impairment

CLC Number:

R749.4

Bin LI,Min HU,Luodong YANG,Ziwei ZHANG,Yuanyuan HU,Guiqing. ZHANG. Relationship between myelin changes in cerebellar gray matter and cognitive function in PTSD[J]. The Journal of Practical Medicine, 2025, 41(14): 2183-2190.

Figures/Tables 7

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References 28

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变量	HC组（n = 30）	PTSD组（n = 30）	t/χ² 值	P值
年龄（x ± s）/岁	38.23 ± 12.14	37.93 ± 12.28	-0.095	0.925
身高（x ± s）/cm	164.30 ± 6.30	166.80 ± 7.95	1.351	0.182
体质量（x ± s）/kg	63.63 ± 10.46	63.57 ± 12.53	-0.022	0.982
BMI（x ± s）/（kg/m2）	23.52 ± 3.36	22.79 ± 3.81	-0.790	0.433
性别			0.000	1.000
男	9（30.00）	9（30.00）
女	21（70.00）	21（70.00）
婚姻状况			3.109	0.211
未婚	12（40.00）	6（20.00）
已婚	14（46.67）	17（56.67）
离异或丧偶	4（13.33）	7（23.33）
教育程度			0.000	1.000
初中	6（20.00）	6（20.00）
中专/高中	9（30.00）	9（30.00）
大专	11（36.67）	11（36.67）
本科及以上	4（13.33）	4（13.33）

项目	HC组（n = 30）	PTSD组（n = 30）	Z值	P值
MoCA总分	27（27，28）	21（16，24）	-6.109	< 0.001
视空间与执行能力	5（4.75，5）	3（1，4）	-6.184	< 0.001
命名	3（3，3）	3（3，3）	-0.440	0.660
注意	5（5，6）	3（2，5）	-5.152	< 0.001
语言	3（2，3）	2（1，2.25）	-4.154	< 0.001
抽象	2（1，2）	1（1，2）	-1.181	0.238
延迟回忆	4（3，4）	2（1，4）	-4.515	< 0.001
定向能力	6（6，6）	6（6，6）	-1.720	0.085

脑区	MNI峰值坐标			T值	团块大小
脑区	X	Y	Z	T值	团块大小
左侧小脑9区	-8	-52	-56	-3.9915	211

项目	r值		P值
项目	9区	8区	9区	8区
MoCA总分	0.625	0.419	< 0.001^a???	0.021^?
视空间与执行能力	0.560	0.457	0.001^a?	0.011^?
命名	0.112	0.481	0.557	0.007^?
注意	0.444	0.263	0.014^?	0.160
语言	0.360	0.257	0.051	0.170
抽象	0.212	0.287	0.262	0.125
延迟回忆	0.351	0.320	0.057	0.084
定向能力	0.373	0.255	0.042^?	0.174

脑区	MNI峰值坐标			T值	团块大小
脑区	X	Y	Z	T值	团块大小
小脑左侧8区	-12	-54	-64.5	-4.781	1 679

Relationship between myelin changes in cerebellar gray matter and cognitive function in PTSD

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