基于光学相干断层成像的血流储备分数在冠心病诊疗中的应用研究进展

doi:10.3969/j.issn.1006-5725.2024.20.023

Abstract

Abstract:

The incidence of coronary heart disease is increasing year by year， with the mortality rate ranking first. Early prevention， diagnosis， and treatment are crucial to reduce the mortality rate. Coronary angiography is the gold standard for diagnosing coronary heart disease and is widely used in clinical practice， but it cannot accurately reflect the degree of coronary artery disease. Blood flow reserve fraction （FFR） is currently the reference standard for evaluating coronary artery stenosis function. However， it is an invasive examination that is limited in clinical application due to factors such as complex operation， high cost， multiple side effects related to vasodilators， and poor reproducibility. In recent years， non-invasive blood flow reserve scores related to imaging have been increasingly applied in clinical practice. Quantitative flow fraction （QFR） and optical coherence tomography based flow reserve fraction （OCT based optical flow ratio OFR） have become research hotspots. OFR， as a relatively new technology， has received increasing attention. Therefore， this article will describe the basic principles， clinical value， and research progress of the above-mentioned technologies.

Key words: blood flow reserve score, quantitative blood flow fraction, blood flow reserve score based on optical coherence tomography, non-invasive blood flow reserve score

CLC Number:

R543.5

Zaili LU,Chaozhong LI,Jie XIA,Yuzhu WU,Ranzun ZHAO. The application value and research progress of blood flow reserve fraction based on optical coherence tomography in coronary heart disease[J]. The Journal of Practical Medicine, 2024, 40(20): 2960-2964.

References 40

1	PIJLS N H， VAN G B， VAN D V P， et al. A useful index to evaluate the influence of an epicardial coronary stenosis on myocardial blood flow［J］. Circulation，1995， 92（11）：3183-3193.
2	PIJLS N H， DE B B， PEELS K， et al. Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses［J］. N Engl J Med， 1996， 334（26）：1703-1708. doi:10.1056/nejm199606273342604 doi: 10.1056/nejm199606273342604
3	ZIMMERMANN F M， FERRARA A， JOHNSON N P， et al. Deferral vs.performance of ercutaneous coronary intervention of functionally non-significant coronary stenosis： 15-year follow-up of the DEFER trial［J］. Eur Heart J， 2015， 36（45）：3182-3188. doi:10.1093/eurheartj/ehv452 doi: 10.1093/eurheartj/ehv452
4	TONIONO P A， DE B B， PIJLS N H， et al.Fractional flow reserve versus angiography for guiding percutaneous coronary intervention［J］. N Engl J Med， 2009， 360（3）：213-224. doi:10.1056/nejmoa0807611 doi: 10.1056/nejmoa0807611
5	PIJLS N H， FEARON W F， TONION P A， et al.Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease： 2-year follow-up of the FAME （Fractional Flow Reserve Versus Angiography for Multivessel Evaluation） study［J］.J Am Coll Cardiol， 2010， 56（3）：177-184.
6	LEE J M， KIM H K， PARK K H， et al.Fractional flow reserve versus angiography-guided strategy in acute myocardial infarction with multivessel disease： A randomized trial［J］.Eur Heart J， 2023， 44（6）：473-484. doi:10.1093/eurheartj/ehac763 doi: 10.1093/eurheartj/ehac763
7	TONION P A， DE B B， PIJLS N H， et al. Fractional flow reserve versus angiography for guiding percutaneous coronary intervention［J］. N Engl J Med， 2009， 360（3）：213-224. doi:10.1056/nejmoa0807611 doi: 10.1056/nejmoa0807611
8	XAPLANTERIS P， FOURNIER S， PIJLS N H， et al.Five-year outcomes with pci guided by fractional flow reserve［J］.N Engl J Med， 2018， 379（3）：250-259. doi:10.1056/nejmoa1803538 doi: 10.1056/nejmoa1803538
9	NEUMANN F J， SOUSA-UVA M， AHLSSON A， et al. 2018 ESC/EACTS Guidelines on myocardial revascularization［J］. Eur Heart J， 2019， 40（2）：87-165. doi:10.1093/eurheartj/ehy855 doi: 10.1093/eurheartj/ehy855
10	中华医学会心血管病学分会介入心脏病学组，中国医师协会心血管内科医师分会血栓防治专业委员会，中华心血管病杂志编辑委员会.中国经皮冠状动脉介入治疗指南（2016）［J］.中华心血管病杂志， 2016， 44（5）：382-400.
11	HU F， DING D， WESTRA J， LI Y，et al. Diagnostic accuracy of optical flow ratio： An individual patient-data meta-analysis［J］. Euro Interv， 2023， 19： e14-e54. doi:10.4244/eij-d-22-01098 doi: 10.4244/eij-d-22-01098
12	DING D， YU W， TANUZIN H， DE M G， et al. Optical flow ratio for assessing stenting result and physiological significance of residual disease［J］. Euro Interv， 2021， 17：e989-e998. doi:10.4244/eij-d-21-00185 doi: 10.4244/eij-d-21-00185
13	TU S， WESTRA J， YANG J，et al.Diagnostic accuracy of fast computational approaches to derive fractional flow reserve from diagnostic coronary angiography： The international multicenter FAVOR pilot study［J］. JACC Cardiovasc Interv， 2016， 9（19）：2024-2035. doi:10.1016/j.jcin.2016.07.013 doi: 10.1016/j.jcin.2016.07.013
14	HUANG J， EMORI H， DING D，et al.Diagnostic performance of intracoronaryopti cal coherence tomography-based versus angiography-based fractional flow reserve for the evaluation of coronary lesions［J］. Euro Interv， 2020， 16（7）：568-576. doi:10.4244/eij-d-19-01034 doi: 10.4244/eij-d-19-01034
15	GUTIERREZ-CHICO J L， WYKRZYKOWSKA J， NUESCH E， et al. Vascular tissue reaction to acute malapposition in human coronary arteries： sequential assessment with optical coherence tomography［J］. Circ Cardiovasc Interv， 2012， 5（1）： 20-29， S1-S8. doi:10.1161/circinterventions.111.965301 doi: 10.1161/circinterventions.111.965301
16	GUTIERREZ-CHICO J L， ALEGRIA-BARRERO E， TEIJEIRO-MESTRE R， et al. Optical coherence tomography： from research to practice［J］. Eur Heart J Cardiovasc Imaging， 2012， 13（5）： 370-384. doi:10.1093/ehjci/jes025 doi: 10.1093/ehjci/jes025
17	ALI Z A， MAEHARA A， GENEREUX P， et al. ILUMIEN III： OPTIMIZE PCI Investigators. Optical coherence tomography compared with intravascular ultrasound and with angiography to guide coronary stent implantation （ILUMIEN III： OPTIMIZE PCI）： A randomised controlled trial［J］. Lancet， 2016， 388（10060）： 2618-2628. doi:10.1016/s0140-6736(16)31922-5 doi: 10.1016/s0140-6736(16)31922-5
18	LI Y， GUTIERREZ-CHICO J L， HOLM N R， et al. Impact of side branch modeling on computation of endothelial shear stress in coronary artery disease： coronary tree reconstruction by fusion of 3D angiography and OCT［J］. J Am Coll Cardiol， 2015， 66（2）： 125-135. doi:10.1016/j.jacc.2015.05.008 doi: 10.1016/j.jacc.2015.05.008
19	YU W， HUANG J， JIA D， et al. Diagnostic accuracy of intracoronary optical coherence tomography-derived fractional flow reserve for assessment of coronary stenosis severity［J］. Euro Interv， 2019， 15（2）：189-197. doi:10.4244/eij-d-19-00182 doi: 10.4244/eij-d-19-00182
20	TIAN F， YU W， HUANG J， et al.First presentation of integration of intravascular optical coherence tomography and computational fractional flow reserve［J］. Int J Cardiovasc Imaging， 2019， 35（4）：601-602. doi:10.1007/s10554-018-1491-1 doi: 10.1007/s10554-018-1491-1
21	JIANG J， DU C， HU Y， et al. Diagnostic performance of computational fluid dynamics （CFD）-based fractional flow reserve （FFR） derived from coronary computed tomographic angiography （CCTA） for assessing functional severity of coronary lesions［J］. Quant Imaging Med Surg， 2023， 13（3）：1672-1685. doi:10.21037/qims-22-521 doi: 10.21037/qims-22-521
22	XU B， TU S， QIAO S， et al. Diagnostic accuracy of angiography-based quantitative flow ratio measurements for online assessment of coronary stenosis［J］. J Am Coll Cardiol， 2017， 70（25）：3077-3087. doi:10.1016/j.jacc.2017.10.035 doi: 10.1016/j.jacc.2017.10.035
23	WESTRA J， ANDERSEN B K， CAMPO G， et al.Diagnostic performance of in-procedure angiography-derived quantitative flow reserve compared to pressure-derived fractional flow reserve： The FAVOR II Europe-Japan study［J］. J Am Heart Assoc， 2018， 7（14）：e009603. doi:10.1161/jaha.118.009603 doi: 10.1161/jaha.118.009603
24	WESTRA J， TU S， WINTER S， et al. Evaluation of coronary artery stenosis by quantitative flow ratio during invasive coronary angiography： The WIFI II study （wire-free functional imaging II）［J］. Circ Cardiovasc Imaging， 2018， 11（3）：e007107. doi:10.1161/circimaging.117.007107 doi: 10.1161/circimaging.117.007107
25	XU B， TU S， SONG L， et al. Angiographic quantitative flow ratio-guided coronary intervention （FAVOR III China）： A multicentre， randomised，sham-controlled trial［J］.Lancet， 2021， 398（10317）：2149-2159. doi:10.1016/s0140-6736(21)02248-0 doi: 10.1016/s0140-6736(21)02248-0
26	CHEN H， LI B， XIAO Y， et al. Diagnostic efficacy of the optical flow ratio in patients with coronary heart disease： A meta-analysis［J］. PLoS One， 2023， 18（5）：e0285508. doi:10.1371/journal.pone.0285508 doi: 10.1371/journal.pone.0285508
27	HONG H， JIA H， ZENG M， et al. Risk Stratification in Acute Coronary Syndrome by Comprehensive Morphofunctional Assessment With Optical Coherence Tomography［J］. JACC Asia， 2022， 2（4）：460-472. doi:10.1016/j.jacasi.2022.03.004 doi: 10.1016/j.jacasi.2022.03.004
28	KAKIZAKI S， OTAKE H， SEIKE F， et al. Optical coherence tomography fractional flow reserve and cardiovascular outcomes in patients with acute coronary syndrome［J］. JACC Cardiovasc Interv， 2022， 15：2035-2048. doi:10.1016/j.jcin.2022.08.010 doi: 10.1016/j.jcin.2022.08.010
29	GAO X F， GE Z， KONG X Q， et al. 3-year outcomes of the ultimate trial comparing intravascular ultrasound versus angiography-guided drugeluting stent implantation［J］. JACC Cardiovasc Interv， 2021， 14：247-257. doi:10.1016/j.jcin.2020.10.001 doi: 10.1016/j.jcin.2020.10.001
30	CSANADI B， FERENCI T， FULOP G，et al. Clinical implications of fractional flow reserve measured immediately after percutaneous coronary intervention［J］. Cardiovasc Drugs Ther， 2023. doi： 10.1007/s10557-023-07437-0 . doi: 10.1007/s10557-023-07437-0
31	STONE G W， MAEHARA A， ALI Z A， et al. Percutaneous coronary intervention for vulnerable coronary atherosclerotic plaque［J］. J Am Coll Cardiol， 2020， 76（20）：2289-2301. doi:10.1016/j.jacc.2020.09.547 doi: 10.1016/j.jacc.2020.09.547
32	KEDHI E， BERTA B， ROLEDER T，et al. Thin-cap fibroatheroma predicts clinical events in diabetic patients with normal fractional flow reserve： the COMBINE OCT-FFR trial.［J］ Eur Heart J， 2021， 42（45）：4671-4679. doi:10.1093/eurheartj/ehab433 doi: 10.1093/eurheartj/ehab433
33	MA X， WANG Q， HU X， et al. Association of sdLDL-C with incident carotid plaques with stable and vulnerable morphology： A prospective cohort study［J］. Stroke， 2024， 55（3）：576-585.
34	马丽娜，曹振华，杨冰. 小而密低密度脂蛋白胆固醇、CXC型趋化因子配体与糖尿病患者并发心血管疾病的相关性［J］. 实用医学杂志，2023，39（22）：2953-2957.
35	CHEN Y， FU Y， WANG S， et al.Clinical significance of neutrophil gelatinase-associated lipocalin and sdLDL-C for coronary artery disease in patients with type 2 diabetes mellitus aged ≥ 65 years［J］. Cardiovasc Diabetol， 2022， 21（1）：252. doi:10.1186/s12933-022-01668-5 doi: 10.1186/s12933-022-01668-5
36	巨名飞，刘超，刘佳梅，等. 急性冠状动脉综合征患者残余胆固醇水平与冠状动脉狭窄严重程度的相关性［J］. 实用医学杂志，2023，39（1）：71-75.
37	TANIGAKI T， EMORI H， KAWASE Y， et al. QFR versus FFR derived from computed tomography for functional assessment of coronary artery stenosis［J］. JACC Cardiovasc Interv， 2019， 12（20）：2050-2059. doi:10.1016/j.jcin.2019.06.043 doi: 10.1016/j.jcin.2019.06.043
38	ZENG X， HOLCK E N， WESTRA J， et al.Impact of coronary plaque morphology on the precision of computational fractional flow reserve derived from optical coherence tomography imaging［J］. Cardiovasc Diagn Ther， 2022， 12（2）：155-165. doi:10.21037/cdt-21-505 doi: 10.21037/cdt-21-505
39	JIA H， ZHAO C， YU H， et al. Clinical performance of a novel hybrid IVUS-OCT system： A multicentre， randomised， non-inferiority trial （PANOVISION）［J］. Euro Interv， 2023， 19（4）：e318-e320. doi:10.4244/eij-d-22-01058 doi: 10.4244/eij-d-22-01058
40	EMORI H， KUBO T， SHIONO Y， et al. Comparison of optical flow ratio and fractional flow ratio in stent-treated arteries immediately after percutaneous coronary intervention［J］. Circ J， 2020， 84（12）：2253-2258. doi:10.1253/circj.cj-20-0661 doi: 10.1253/circj.cj-20-0661

[1]	Yushan CHEN,Tingting WANG,Xinyi HAN,Chengjun HUA,Boyuan JIN,Shasha SHANG,Yonghua ZONG,Yazhou. LIANG. Effect of M1 macrophage polarization regulated by berberine combined with curcumin on atherosclerosis [J]. The Journal of Practical Medicine, 2024, 40(14): 1915-1921.
[2]	Rui ZHONG,Jianing WANG,Lei ZHANG,Lingyun GUO,Jianye YANG,Fei ZHENG,Yuwen YAN,Danli YU,Liguo. TAN. Experimental study on treatment of severe limb ischemia with Ad⁃hVEGF⁃hHGF gene [J]. The Journal of Practical Medicine, 2024, 40(5): 639-645.
[3]	Xiaoyan WANG,Xiaoyi ZOU,Xiang ZHU,Ting WANG,Yetao QIANG,Siyuan ZHOU,Peng ZHANG,Ping ZHANG. Iron overload regulates atherosclerotic activity of foam cells induced by oxLDL [J]. The Journal of Practical Medicine, 2024, 40(3): 295-301.
[4]	Tingting WANG,Lili YU,Xiangli SHEN,Junmeng ZHENG,Yushan CHEN,Shasha SHANG,Jianru. WANG. Application and research progress of nanotechnology in atherosclerosis [J]. The Journal of Practical Medicine, 2024, 40(1): 53-58.
[5]	Haozhe ZHENG,Bing WANG,Xiaoyang NIU,Wenjun CUI,Ling WANG,Zhengzuo LÜ. Clinical efficacy of drugeluting stents for femoral popliteal arteriosclerosis obliterans [J]. The Journal of Practical Medicine, 2023, 39(21): 2796-2801.
[6]	Zhixian JI,Gang LUO,Sibao WANG,Kuiliang WANG,Silin. PAN. Role of left ventricular morphology combined with ST segment depression in prediction of postoperative cardiac dysfunction in infants with patent ductus arteriosus [J]. The Journal of Practical Medicine, 2023, 39(16): 2057-2061.

The application value and research progress of blood flow reserve fraction based on optical coherence tomography in coronary heart disease

RichHTML

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References 40

Related Articles 6

Recommended Articles

Metrics

Comments