纳米技术在动脉粥样硬化中的应用与研究进展

doi:10.3969/j.issn.1006-5725.2024.01.010

Abstract

Abstract:

Atherosclerosis （AS） is a common cardiovascular disease， and its treatment and prevention have been the focus of medical research. AS an emerging technology， nanotechnology has unique advantages and plays an important role in the prevention， diagnosis and treatment of AS. This paper reviews the latest research on the application of nanotechnology in AS diseases， systematically discusses the role of nanotechnology in the diagnosis and treatment of AS， and comprehensively analyzes the effects of nano-drug carriers based on different surface trimmers， loading diagnostic and therapeutic drugs so as to monitordisease progression of AS and its targeted treatment. The aim is to provide new thought for the clinical treatment of AS.

Key words: atherosclerosis, nanotechnology, targeting effect, nanoprobe

CLC Number:

R543.5

Tingting WANG,Lili YU,Xiangli SHEN,Junmeng ZHENG,Yushan CHEN,Shasha SHANG,Jianru. WANG. Application and research progress of nanotechnology in atherosclerosis[J]. The Journal of Practical Medicine, 2024, 40(1): 53-58.

Figures/Tables 2

References 38

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纳米修饰	纳米药物名称	药物类型	作用机制
cRGDfc肽	cRGDfc/RAP-Nps^[26]	3-羟基-3-甲基戊二酰辅酶	调节炎症微环境
S2P肽	DSPE?PEG?S2P ^[27]	siRNA	抑制CaMKIIγ
CCR2靶向肽	DSPE-PEG(2000)-miR-145^[28]	miR-145	调节平滑肌表型
脂化肽	ST@MLP-NVs^[29]	辛伐他汀	促进斑块中基质金属蛋白酶2的释放
胶束	TPGS^[30]	黄连素	上调p-AMPK、下调NF-κB
双金属（树莓状铂、铈）	DPTP NRs^[31]	替格瑞洛	激活P2Y12-cAMP/p-VASP通路
金属（MnO₂）	Cur?MnO2/HA NPs^[32]	姜黄素	抑制巨噬细胞极化
β-环糊精	CSNP^[33]	辛伐他汀	消除胆固醇结晶
血小板膜	RAP@PLT NPs^[34]	雷帕霉素	维持斑块稳定
血小板膜	PM@Se/Rb1 NPs^[35]	硒/人参皂苷	抗血管生成
仿生物膜	HA-M@PB@(PC+ART) NPs^[36]	青霉素/原花青素	增强AMPK/mTOR自噬途径
二氧化硅	MSNs@anti-IL-1β^[37]	抗白介素-1β	抑制平滑肌细胞增殖和表型切换
褐藻酸	P-21NPs^[38]	P-4	促进胆固醇外排

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Application and research progress of nanotechnology in atherosclerosis

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