Abstract:

Objective To explore the short and medium⁃term efficacy of biomimetic collagen⁃modified PM⁃ MA bone cement in the treatment of single segment osteoporotic thoracolumbar compression fractures（OVCF）. Methods 120 patients with single vertebral osteoporotic thoracolumbar compression fractures admitted to our hospital from May 2017 to June 2019 were randomly divided into control group and treatment group，60 for each group. PMMA bone cement was used for percutaneous kyphoplasty in the control group，while biomimetic mineralized collagen ⁃modified PMMA bone cement was used for percutaneous kyphoplasty in the treatment group. VAS score and oswestry disability index scale（ODI）were recorded presurgically and at postsurgical day 2 and months 3 and 6，and sagittal plane index，Cobb Angle and bone cement distribution in the vertebra were measured. Results There were statistical significant differences in VAS score ，ODI score，sagittal plane index and Cobb Angle between the two groups at preoperative and postoperative day 2 and months 3 and 6，while there were no statistical significant differences between the two groups in the postoperative observation time points，and there were no statis⁃ tical significant differences between the two groups in the same postoperative observation time points. 13 patients were in the control group and 10 in the treatment group. Recurrent low back pain occurred in two patients in the control group 6 months after surgery，but not in the treatment group. Conclusions The short and medium⁃term efficacy of biomimetic mineralized collagen ⁃ modified PMMA bone cement is equivalent to that of single PMMA bone cement in the treatment of single segment osteoporotic thoracolumbar compression fracture. The number of complications was less in the treatment group than in the control group，but the difference was not statistically significant，requiring larger sample size and long⁃term observation.

Key words:

biomimetic mineralized collagen, modification of PMMA bone cement, osteoporotic compression fracture