微生物-肠-脑通讯对心脏骤停后脑损伤神经炎症的影响

doi:10.3969/j.issn.1006-5725.2025.06.021

Abstract

Abstract:

Cardiac arrest is a major health event that poses a major threat to human life and health. Post-cardiac arrest brain injury is the main adverse prognostic factor and cause of death in patients who experience cardiac arrest. Currently， the therapeutic methods and effects are limited. In recent years， with the in-depth research on microbiota-gut-brain communication， it has been found that intestinal microbiota and their metabolites may play a role in the regulation of neuroinflammation in post-cardiac arrest brain injury. Short-chain fatty acids are the key substances in microbiota-gut-brain communication， and the mechanism involves immune， endocrine and neuroregulatory pathways. Supplementation of short-chain fatty acid-producing bacteria or short-chain fatty acids can improve intestinal flora disorder and reduce neuroinflammation after cardiopulmonary resuscitation. As a key mediator in microbial-gut-brain communication， short-chain fatty acids have great potential for the treatment of brain injury after cardiac arrest. This review explores the role and regulatory mechanism of microbiota-gut-brain communication in the neuroinflammation of brain injury after cardiopulmonary resuscitation through immune， endocrine and neuroregulatory pathways， providing a new idea for the treatment of post-cardiac arrest brain injury.

Key words: cardiac arrest, post-cardiac arrest brain injury, short-chain fatty acid, microbiota-gut-brain axis

CLC Number:

R459.9

Haojun ZHANG,Mei JING,Yufeng ZHU,Tianpeng XU,Xi CHEN,Rongyi SHI,Yi. SHAN. Impact of microbiota⁃gut⁃brain axis on neuroinflammation after post⁃cardiac arrest brain injury[J]. The Journal of Practical Medicine, 2025, 41(6): 911-915.

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Impact of microbiota⁃gut⁃brain axis on neuroinflammation after post⁃cardiac arrest brain injury

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